Titel (eng)

The Gastrointestinal Microbiota as a Potential Cause and Target in Chronic Kidney Disease Accentuating Treatment and Intervention Strategies

Autor*in

Ana Zupcic   University of Veterinary Medicine, Vienna

Paul Slezak

Judith Radloff   University of Veterinary Medicine, Vienna

Verlag

MDPI

Beschreibung (eng)

Dysbiosis and impaired gastrointestinal barrier function have emerged as potential chronic kidney disease (CKD) modulators. Accumulation of gut-derived uremic toxins, a subsequent shift in the gut microbiome, and modified expression levels of intestinal tight junction proteins are all contributing factors to hyperpermeability and endotoxemia in CKD. Experimental studies in animals provide evidence that renal decline is linked to gastrointestinal health and that pharmacological or dietary intervention might attenuate this process. In this review, we will highlight the current knowledge on CKD-induced changes in the gut microbiome and the resulting consequences regarding gastrointestinal health with a focus on animal studies. Furthermore, we will explore possible disease management options linking to evidence in humans, if available.

Sprache des Objekts

Englisch

Datum

2023

Rechte

Dieses Werk bzw. dieser Inhalt steht unter einer
CC BY 4.0 - Creative Commons Namensnennung 4.0 International Lizenz.

CC BY 4.0 International

http://creativecommons.org/licenses/by/4.0/

Klassifikation

All-Cause Mortality; P-Cresyl Sulfate; Tight Junction; Vitamin-D; Dependent Phosphate; Bardoxolone Methyl; Gut Microbiome; Ckd; Barrier; Supplementation

Mitglied in der/den Collection(s) (1)