o:1501 The Gastrointestinal Microbiota as a Potential Cause and Target in Chronic Kidney Disease Accentuating Treatment and Intervention Strategies en Dysbiosis and impaired gastrointestinal barrier function have emerged as potential chronic kidney disease (CKD) modulators. Accumulation of gut-derived uremic toxins, a subsequent shift in the gut microbiome, and modified expression levels of intestinal tight junction proteins are all contributing factors to hyperpermeability and endotoxemia in CKD. Experimental studies in animals provide evidence that renal decline is linked to gastrointestinal health and that pharmacological or dietary intervention might attenuate this process. In this review, we will highlight the current knowledge on CKD-induced changes in the gut microbiome and the resulting consequences regarding gastrointestinal health with a focus on animal studies. Furthermore, we will explore possible disease management options linking to evidence in humans, if available. Chronic Kidney Disease Dysbiosis Gastrointestinal Hyperpermeability Gut Microbiome Leaky Gut Syndrome 1552099 10.3390/app13053212 2023-04-13T15:15:13.153Z 44 yes 46 Ana Zupcic University of Veterinary Medicine Vienna Paul Slezak person Judith Radloff University of Veterinary Medicine Vienna person 0000-0002-8541-2076 application/pdf 1285791 https://phaidra.vetmeduni.ac.at/o:1501 no yes 16 70 1552253 Applied Sciences 17 13 5 MDPI 2023