https://phaidra.vetmeduni.ac.at/o:1501 The Gastrointestinal Microbiota as a Potential Cause and Target in Chronic Kidney Disease Accentuating Treatment and Intervention Strategies Zupcic, Ana Ana Zupcic University of Veterinary Medicine Vienna Slezak, Paul Paul Slezak Radloff, Judith Judith Radloff 0000-0002-8541-2076 University of Veterinary Medicine Vienna MDPI text eng Dysbiosis and impaired gastrointestinal barrier function have emerged as potential chronic kidney disease (CKD) modulators. Accumulation of gut-derived uremic toxins, a subsequent shift in the gut microbiome, and modified expression levels of intestinal tight junction proteins are all contributing factors to hyperpermeability and endotoxemia in CKD. Experimental studies in animals provide evidence that renal decline is linked to gastrointestinal health and that pharmacological or dietary intervention might attenuate this process. In this review, we will highlight the current knowledge on CKD-induced changes in the gut microbiome and the resulting consequences regarding gastrointestinal health with a focus on animal studies. Furthermore, we will explore possible disease management options linking to evidence in humans, if available. Chronic Kidney Disease Dysbiosis Gastrointestinal Hyperpermeability Gut Microbiome Leaky Gut Syndrome http://creativecommons.org/licenses/by/4.0/ https://phaidra.vetmeduni.ac.at/api/object/o:1501/download 10.3390/app13053212 https://phaidra.vetmeduni.ac.at/o:605 application/pdf Applied Sciences 13(5) (2023) Applied Sciences 13 5 1.23 MB 2023