phaidra.vetmeduni.ac.at o:1501 DOI 10.3390/app13053212 The Gastrointestinal Microbiota as a Potential Cause and Target in Chronic Kidney Disease Accentuating Treatment and Intervention Strategies Dysbiosis and impaired gastrointestinal barrier function have emerged as potential chronic kidney disease (CKD) modulators. Accumulation of gut-derived uremic toxins, a subsequent shift in the gut microbiome, and modified expression levels of intestinal tight junction proteins are all contributing factors to hyperpermeability and endotoxemia in CKD. Experimental studies in animals provide evidence that renal decline is linked to gastrointestinal health and that pharmacological or dietary intervention might attenuate this process. In this review, we will highlight the current knowledge on CKD-induced changes in the gut microbiome and the resulting consequences regarding gastrointestinal health with a focus on animal studies. Furthermore, we will explore possible disease management options linking to evidence in humans, if available. eng Chronic Kidney Disease Dysbiosis Gastrointestinal Hyperpermeability Gut Microbiome Leaky Gut Syndrome 2023-04-13T15:22:05.337Z LOMv1.0 Author BEGIN:VCARD VERSION:3.0 N:Zupcic;Ana; FN:Ana Zupcic END:VCARD BEGIN:VCARD VERSION:3.0 N:Slezak;Paul; FN:Paul Slezak END:VCARD BEGIN:VCARD VERSION:3.0 N:Radloff;Judith; FN:Judith Radloff X-ORCID:https://orcid.org/0000-0002-8541-2076 END:VCARD https://w3id.org/kim/hcrt/scheme https://w3id.org/kim/hcrt/text Textdokument Text LOMv1.0 yes https://creativecommons.org/licenses/by/4.0 application/pdf 1285791 https://phaidra.vetmeduni.ac.at/o:1501 https://phaidra.vetmeduni.ac.at/api/object/o:1501/thumbnail LOMv1.0 discipline