Titel (eng)

One Health Surveillance Highlights Circulation of Viruses with Zoonotic Potential in Bats, Pigs, and Humans in Viet Nam

Autor*in

Amanda E. Fine   Wildlife Conservation Society

Sarah H Olson   Wildlife Conservation Society

Chris Walzer   University of Veterinary Medicine, Vienna

Jonna A K Mazet   University of California

Christine K Johnson   University of California

Pawin Padungtod   Food and Agriculture Organization of the United Nations

Ken Inui   Food and Agriculture Organization of the United Nations

Keersten Ricks   U.S. Army Medical Research Institute of Infectious Diseases

Randal Schoepp   U.S. Army Medical Research Institute of Infectious Diseases

Nguyen Duc Thinh   Ministry of Health

Vu Trong Duoc   Ministry of Health

Vu Sinh Nam   Ministry of Health

Nguyen Tung   Ministry of Agricultural and Rural Development of Viet Nam

Le Tin Vinh Quang   

Nguyen Thanh Phuong   

Pham Thanh long   Ministry of Agricultural and Rural Development of Viet Nam

Nguyen Van Long   Ministry of Agricultural and Rural Development of Viet Nam

Hoang Bich Thuy   Wildlife Conservation Society

Pham Thi Bich Ngoc   Wildlife Conservation Society

Nguyen Van Long   Wildlife Conservation Society

Alice Latinne   Wildlife Conservation Society

Nguyen Thi Thanh Nga   Wildlife Conservation Society

  Predict Consortium

Verlag

MDPI

Beschreibung (eng)

A One Health cross-sectoral surveillance approach was implemented to screen biological samples from bats, pigs, and humans at high-risk interfaces for zoonotic viral spillover for five viral families with zoonotic potential in Viet Nam. Over 1600 animal and human samples from bat guano harvesting sites, natural bat roosts, and pig farming operations were tested for coronaviruses (CoVs), paramyxoviruses, influenza viruses, filoviruses and flaviviruses using consensus PCR assays. Human samples were also tested using immunoassays to detect antibodies against eight virus groups. Significant viral diversity, including CoVs closely related to ancestors of pig pathogens, was detected in bats roosting at the human-animal interfaces, illustrating the high risk for CoV spillover from bats to pigs in Viet Nam, where pig density is very high. Season and reproductive period were significantly associated with the detection of bat CoVs, with site-specific effects. Phylogeographic analysis indicated localized viral transmission among pig farms. Our limited human sampling did not detect any known zoonotic bat viruses in human communities living close to the bat cave and harvesting bat guano, but our serological assays showed possible previous exposure to Marburg virus-like (Filoviridae), Crimean-Congo hemorrhagic fever virus-like (Bunyaviridae) viruses and flaviviruses. Targeted and coordinated One Health surveillance helped uncover this viral pathogen emergence hotspot.

Sprache des Objekts

Englisch

Datum

2023

Rechte

Dieses Werk bzw. dieser Inhalt steht unter einer
CC BY 4.0 - Creative Commons Namensnennung 4.0 International Lizenz.

CC BY 4.0 International

http://creativecommons.org/licenses/by/4.0/

Klassifikation

Encephalitis-Virus; Usutu-Virus; Nipah Virus; Coronavirus; Identification; Paramyxovirus; Chiroptera; History; Origin; Growth

Mitglied in der/den Collection(s) (1)