Allergic Rhinitis and Its Impact on Asthma (ARIA)-EAACI Guidelines—2024–2025 Revision: Part I—Guidelines on Intranasal Treatments
Title (eng)
Allergic Rhinitis and Its Impact on Asthma (ARIA)-EAACI Guidelines—2024–2025 Revision: Part I—Guidelines on Intranasal Treatments
Author
Bernardo Sousa‐Pinto
MEDCIDS—Department of Community Medicine, Information and Health Decision Sciences, Faculty of Medicine University of Porto Porto Portugal
Jean Bousquet
Institute of Allergology Charité—Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt‐Universität Zu Berlin Berlin Germany
Rafael José Vieira
MEDCIDS—Department of Community Medicine, Information and Health Decision Sciences, Faculty of Medicine University of Porto Porto Portugal
Holger J. Schünemann
Fraunhofer Institute for Translational Medicine and Pharmacology ITMP, Immunology and Allergology Berlin Germany
Torsten Zuberbier
Institute of Allergology Charité—Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt‐Universität Zu Berlin Berlin Germany
Antonio Bognanni
Department of Health Research Methods, Evidence, and Impact & Department of Medicine McMaster University Hamilton Ontario Canada
Alkis Togias
Division of Allergy, Immunology, and Transplantation (DAIT) National Institute of Allergy and Infectious Diseases, NIH Bethesda Maryland USA
Boleslaw Samolinski
Department of Prevention of Environmental Hazards, Allergology and Immunology Medical University of Warsaw Warsaw Poland
Arunas Valiulis
Institute of Clinical Medicine and Institute of Health Sciences Medical Faculty of Vilnius University Vilnius Lithuania
Sian Williams
International Primary Care Respiratory Group IPCRG Edinburgh UK
Anna Bedbrook
ARIA (Allergic Rhinitis and Its Impact on Asthma) Montpellier France
Wienczyslawa Czarlewski
ARIA (Allergic Rhinitis and Its Impact on Asthma) Montpellier France
Maria Jose Torres
Allergy Unit Málaga Regional University Hospital of Málaga, Malaga University, ARADyAL Malaga Spain
Mohamed H. Shamji
Immunomodulation and Tolerance Group and Allergy and Clinical Immunology Imperial College London London UK
G. Walter Canonica
Department of Biomedical Science Humanitas University, Pieve Emanuele Milan Italy
Leticia de las Vecillas
Department of Allergy Hospital La Paz Institute for Health Research (IdiPAZ) Madrid Spain
Mark S. Dykewicz
Section of Allergy and Immunology Saint Louis University School of Medicine Saint Louis Missouri USA
Cristina Jacomelli
“Respiriamo Insieme” Association, Asthma & Allergy Center Padova Italy
Ludger Klimek
Department of Otolaryngology, Head & Neck Surgery Universitätsmedizin Mainz Mainz Germany
Lucas Leemann
Department of Political Science University of Zürich Zürich Switzerland
Olga Lourenço
RISE‐Health, Department of Medical Sciences Faculty of Health Sciences, University of Beira Interior Covilhã Portugal
Yuliia Palamarchuk
Finnish Meteorological Institute (FMI) Atmospheric Composition Research Helsinki Finland
Nikolaos G. Papadopoulos
Allergy Department 2nd Pediatric Clinic, University of Athens Athens Greece
Ana Margarida Pereira
MEDCIDS—Department of Community Medicine, Information and Health Decision Sciences, Faculty of Medicine University of Porto Porto Portugal
Sanna K. Toppila‐Salmi
Department of Allergy, Skin and Allergy Hospital, Inflammation Center Helsinki University Hospital and University of Helsinki Helsinki Finland
Maria Teresa Ventura
University of Bari Medical School Bari Italy
Juan José Yepes‐Nuñez
School of Medicine Universidad de los Andes Bogotá D. C. Colombia
Alvaro A. Cruz
Fundacao ProAR and (Faculdade de Medicina da) Universidade Federal da Bahia Salvador Bahia Brazil
Giorgio Ciprandi
Casa di Cura Villa Montallegro Allergology Department Genova Italy
Bilun Gemicioglu
Department of Pulmonary Diseases and Institute of Pulmonology and Tuberculosis Istanbul University‐Cerrahpaşa, Cerrahpaşa Faculty of Medicine Istanbul Turkey
Brigita Gradauskiene
Department of Immunology and Allergology Lithuanian University of Health Sciences Kaunas Lithuania
Tuomas Jartti
Department of Pediatrics and Adolescent Medicine University of Turku, Turku University Hospital Turku Finland
Miloš Jeseňák
Institute of Clinical Immunology and Medical Genetics, Department of Paediatrics and Adolescent Medicine, Department of Pulmonology and Phthisiology Jessenius Faculty of Medicine Martin Slovakia
Piotr Kuna
Division of Internal Medicine, Asthma and Allergy Barlicki University Hospital, Medical University of Lodz Lodz Poland
Violeta Kvedariene
Institute of Clinical Medicine, Clinic of Chest Diseases and Allergology, Faculty of Medicine Vilnius University Vilnius Lithuania
Désirée E. Larenas‐Linnemann
Center of Excellence in Asthma and Allergy Médica Sur Clinical Foundation and Hospital México City Mexico
Amir HA Latiff
Allergy & Immunology Centre Pantai Hospital Kuala Lumpur Kuala Lumpur Malaysia
Yousser Mohammad
National Center for Research in Chronic Respiratory Diseases, Collaborating With WHO—EMRO Tishreen University School of Medicine Latakia Syria
Ken Ohta
Japan Antituberculosis Association (JATA) Fukujuji Hospital Tokyo Japan
Padukudru A. Mahesh
Department of Respiratory Medicine JSS Medical College, JSSAHER Mysuru Mysore Karnataka India
Isabella Pali‐Schöll
Departement of Biological Sciences and Pathophysiology, University of Veterinary Medicine, Vienna, Austria
Oliver Pfaar
Section of Rhinology and Allergy, Department of Otorhinolaryngology, Head and Neck Surgery University Hospital Marburg, Philipps‐Universität Marburg Marburg Germany
Frederico S. Regateiro
Allergy and Clinical Immunology Department Hospitais da Universidade de Coimbra, Unidade Local de Saúde de Coimbra Coimbra Portugal
Nicolas Roche
Pneumologie AP‐HP Centre Université de Paris Cité, Hôpital Cochin Paris France
Luís Taborda‐Barata
UBIAir—Clinical & Experimental Lung Centre and CICS‐UBI Health Sciences Research Centre University of Beira Interior Covilhã Portugal
Charlotte Suppli Ulrik
Department of Respiratory Medicine Copenhagen University Hospital‐Hvidovre Copenhagen Denmark
Marylin Valentin Rostan
Pediatrics, Allergy & Immunology, Latín American Society of Allergy Asthma & Immunology (SLAAi) Montevideo Uruguay
Giovanni Viegi
Pulmonary Environmental Epidemiology Unit CNR Institute of Clinical Physiology Pisa Italy
Luo Zhang
Department of Otolaryngology, Head and Neck Surgery Beijing TongRen Hospital and Beijing Institute of Otolaryngology Beijing China
Tari Haahtela
Skin and Allergy Hospital Helsinki University Hospital, and University of Helsinki Helsinki Finland
Juan Carlos Ivancevich
Servicio de Alergia e Immunologia Clinica Santa Isabel Buenos Aires Argentina
Nikolai Khaltaev
Global NCD Platform Geneva Switzerland
Arzu Yorgancioglu
Department of Pulmonary Diseases Celal Bayar University, Faculty of Medicine Manisa Turkey
Baharudin Abdullah
Department of Otorhinolaryngology—Head and Neck Surgery, School of Medical Sciences Universiti Sains Malaysia Kubang Kerian Kelantan Malaysia
Mona Al‐Ahmad
Microbiology Department College of Medicine, Kuwait University Kuwait City Kuwait
Rita Amaral
MEDCIDS—Department of Community Medicine, Information and Health Decision Sciences, Faculty of Medicine University of Porto Porto Portugal
Karl‐C Bergmann
Institute of Allergology Charité—Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt‐Universität Zu Berlin Berlin Germany
Jonathan A. Bernstein
Division of Immunology, Allergy and Rheumatology, Department of Medicine University of Cincinnati College of Medicine Cincinnati Ohio USA
Michael S. Blaiss
Department of Pediatrics Medical College of Georgia at Augusta University Augusta Georgia USA
Fulvio Braido
Department of Internal Medicine (DIMI) University of Genoa Genoa Italy
Paulo Camargos
Department of Pediatrics, Medical School Federal University of Minas Gerais Belo Horizonte Brazil
Pedro Carreiro‐Martins
NOVA Medical School/Comprehensive Health Research Centre (CHRC) Lisbon Portugal
Thomas Casale
Division of Allergy/Immunology University of South Florida Tampa Florida USA
Alessandro Fiocchi
Allergy, Bambino Gesù Children's Hospital Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Rome Italy
Antonio F. M. Giuliano
Department of Internal Medicine ‘A. Murri’ and Unit of Geriatric Immunoallergology University of Bari Medical School Bari Italy
George Christoff
Faculty of Public Health Sofia Medical University Sofia Bulgaria
Ieva Cirule
Latvian Association of Allergists University Children Hospital Riga Latvia
Jaime Correia de Sousa
Life and Health Sciences Research Institute (ICVS), School of Medicine University of Minho Braga Portugal
Elisio M. Costa
CINTESIS@RISE, Biochemistry Lab, Faculty of Pharmacy and Competence Center on Active and Healthy Ageing University of Porto Porto Portugal
Stefano Del Giacco
Department of Medical Sciences and Public Health and Unit of Allergy and Clinical Immunology University Hospital “Duilio Casula”, University of Cagliari Cagliari Italy
Philippe Devillier
VIM Suresnes, UMR 0892, Pôle Des Maladies Des Voies Respiratoires, Hôpital Foch Université Paris‐Saclay Suresnes France
Dejan Dokic
Medical Faculty Skopje University Clinic of Pulmology and Allergy Skopje Republic of North Macedonia
Elham Hossny
Pediatric Allergy, Immunology and Rheumatology Unit Children's Hospital, Ain Shams University Cairo Egypt
Carla Irani
Department of Internal Medicine and Infectious Diseases St Joseph University, Hotel Dieu de France Hospital Beirut Lebanon
Zhanat Ispayeva
Department of Allergology and Clinical Immunology, Kazakhstan Association of Allergology and Clinical Immunology Kazakh National Medical University Almaty Kazakhstan
Kaja Julge
Institute of Clinical Medicine Children's Clinic, Tartu University Tartu Estonia
Igor Kaidashev
Poltava State Medical University Immunology & Allergology Department Poltava Ukraine
Kazi S. Bennoor
Department of Respiratory Medicine National Institute of Diseases of the Chest and Hospital Dhaka Bangladesh
Helga Kraxner
Department of Otorhinolaryngology, Head and Neck Surgery Semmelweis University Budapest Hungary
Inger Kull
Department of Clinical Science and Education Södersjukhuset, Karolinska Institutet Stockholm Sweden
Marek Kulus
Department of Pediatric Respiratory Diseases and Allergology Medical University of Warsaw Warsaw Poland
Maciej Kupczyk
Division of Internal Medicine, Asthma and Allergy Barlicki University Hospital, Medical University of Lodz Lodz Poland
Andriy Kurchenko
Department of Clinical and Laboratory Immunology, Allergology and Medical Genetics Bogomolets National Medical University Kyiv Ukraine
Stefania La Grutta
Institute of Translational Pharmacology (IFT)‐National Research Council (CNR) Palermo Italy
Neven Miculinic
Croatian Pulmonary Society Clinical Center for Pulmonary Diseases Zagreb Croatia
Lan Le Thi Tuyet
Asthma, COPD Outpatient Care Unit University Medical Center Hô‐Chi‐Minh City Vietnam
Michael Makris
Allergy Unit “D Kalogeromitros”, 2nd Department of Dermatology and Venereology, National & Kapodistrian University of Athens “Attikon” University Hospital Athens Greece
Branislava Milenkovic
Clinic for Pulmonary Diseases, Clinical Center of Serbia, Faculty of Medicine University of Belgrade, Serbian Association for Asthma and COPD Belgrade Serbia
Sang Min Lee
Division of Respiratory Disease and Allergy, Department of Internal Medicine Dankook University College of Medicine Cheonan Republic of Korea
Stephen Montefort
Department of Medicine, Faculty of Medicine and Surgery University of Malta Msida Malta
Andre Moreira
EPIUnit‐Institute of Public Health University of Porto, and Laboratory for Integrative and Translational Research in Population Health (ITR) Porto Portugal
Joaquim Mullol
Rhinology Unit & Smell Clinic, ENT Department Hospital Clínic Barcelona Spain
Alla Nakonechna
Imperial College Healthcare NHS Trust London UK
Hugo E. Neffen
Center of Allergy, Immunology and Respiratory Diseases Santa Fe Argentina
Dieudonné Nyembue
ENT Department University Hospital of Kinshasa Kinshasa Democratic Republic of the Congo
Robyn E. O'Hehir
Allergy, Asthma and Clinical Immunology, Alfred Health and Department of Immunology, Central Clinical School Monash University Melbourne Victoria Australia
Ismail Ogulur
Swiss Institute of Allergy and Asthma Research (SIAF) University of Zurich Davos Switzerland
Yoshitaka Okamoto
Chiba Rosai Hospital ENT Department Chiba Japan
Heidi Olze
Department of Otorhinolaryngology Charité—Universitätsmedizin Berlin Berlin Germany
Oscar Palomares
Department of Biochemistry and Molecular Biology, School of Chemistry Complutense University of Madrid Madrid Spain
Petr Panzner
Department of Immunology and Allergology, Faculty of Medicine in Pilsen Charles University Prague Czech Republic
Vincenzo Patella
Division of Allergy and Clinical Immunology Department of Medicine, “Santa Maria della Speranza” Hospital, Battipaglia Salerno Italy
Constantinos Pitsios
Medical School University of Cyprus Nicosia Cyprus
Todor A. Popov
Clinic of Occupational Diseases University Hospital Sveti Ivan Rilski Sofia Bulgaria
Francesca Puggioni
IRCCS Humanitas Research Center Personalized Medicine Asthma & Allergy, Rozzano Milan Italy
Santiago Quirce
Department of Allergy Hospital La Paz Institute for Health Research (IdiPAZ) Madrid Spain
Agné Ramonaité
Department of Pulmonology and Allergology Klaipeda National Hospital Klaipėda Lithuania
Marysia Recto
Division of Adult and Pediatric Allergy and Immunology University of the Philippines—Philippines General Hospital Manila Philippines
Maria Susana Repka‐Ramirez
Department of Allergy Clinics Hospital, National University San Lorenzo Paraguay
Menachem Rottem
Division of Allergy, Asthma and Clinical Immunology Emek Medical Center Afula Israel
Marianella Salapatas
Aria Asthma, Rhinitis, Immunology & Allergy Department Athens Greece
Joaquin Sastre
Allergy Service, Fundacion Jimenez Diaz Autonoma University of Madrid, CIBERES‐ISCIII Madrid Spain
Nicola Scichilone
PROMISE Department University of Palermo Palermo Italy
Juan‐Carlos Sisul
Allergy & Asthma Medical Director, CLINICA SISUL, FACAAI, SPAAI Asuncion Paraguay
Dirceu Solé
Division of Allergy, Clinical Immunology and Rheumatology, Department of Pediatrics Federal University of São Paulo São Paulo Brazil
Manuel E. Soto‐Martinez
Division of Respiratory Medicine, Department of Pediatrics Hospital Nacional de Niños, Universidad de Costa Rica San Jose Costa Rica
Milan Sova
Department of Respiratory Medicine and Tuberculosis University Hospital Brno Czech Republic
Pongsakorn Tantilipikorn
Department of Otolaryngology, Faculty of Medicine Siriraj Hospital Mahidol University Bangkok Thailand
Ana Todo‐Bom
Imunoalergologia, Centro Hospitalar Universitário de Coimbra, Faculty of Medicine University of Coimbra Coimbra Portugal
Vladyslav Tsaryk
Department of Clinical and Laboratory Immunology, Allergology and Medical Genetics Bogomolets National Medical University Kyiv Ukraine
Ioanna Tsiligianni
International Primary Care Respiratory Group IPCRG Aberdeen UK
Marilyn Urrutia‐Pereira
Federal University of Pampa Department of Medicine Uruguaiana Brazil
Erkka Valovirta
Department of Lung Diseases and Clinical Immunology University of Turku Turku Finland
Tuula Vasankari
FiLHA Finnish Lung Health Association Helsinki Finland
Dana Wallace
Nova Southeastern University College of Allopathic Medicine Fort Lauderdale Florida USA
De Yun Wang
Department of Otolaryngology Yong Loo Lin School of Medicine, National University of Singapore Singapore Republic of Singapore
Margitta Worm
Division of Allergy and Immunology, Department of Dermatology, Allergy and Venerology Charité Universitätsmedizin Berlin Berlin Germany
Osman M. Yusuf
The Allergy and Asthma Institute Allergy & Asthma Department Islamabad Pakistan
Mihaela Zidarn
University Clinic of Respiratory and Allergic Diseases Pulmonary & Allergy Department Golnik Slovenia
Sara Gil‐Mata
MEDCIDS—Department of Community Medicine, Information and Health Decision Sciences, Faculty of Medicine University of Porto Porto Portugal
Manuel Marques‐Cruz
MEDCIDS—Department of Community Medicine, Information and Health Decision Sciences, Faculty of Medicine University of Porto Porto Portugal
Bassam Mahboub
Pulmonary Department Rashid Hospital, DUBAI Health Dubai UAE
Ignacio J. Ansotegui
Department of Allergy and Immunology Hospital Quironsalud Bizkaia Bilbao Spain
Antonino Romano
Oasi Research Institute‐IRCCS Troina Italy
Werner Aberer
Department of Dermatology Medical University of Graz Graz Austria
Maria Cristina Artesani
Allergy, Bambino Gesù Children's Hospital Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Rome Italy
Elena Azzolini
Asthma & Allergy Unit IRCCS Humanitas Research Hospital, Rozzano Milan Italy
Bruno Barreto
Department of Allergy and Immunology Para State University Center—CESUPA Belém Brazil
Joan Bartra
Allergy Department Hospital Clinic and IDIBAPS. Universitat de Barcelona Barcelona Spain
Sven Becker
Department for Otorhinolaryngology, Head and Neck Surgery University of Tübingen Tübingen Germany
Bianca Beghe
Respiratory Medicine University of Modena & Reggio Emilia, Azienda Ospedaliera‐Universitaria di Modena Modena Italy
Attilio Boner
Pediatric Unit, Department of Surgical Sciences, Dentistry, Gynecology and Pediatrics University of Verona Verona Italy
Ewa Borowiack
Evidence Prime Kraków Poland
Jacques Bouchard
Laval University Quebec City Quebec Canada
Melisande Bourgoin‐Heck
Department of Pediatric Allergology Armand Trousseau University Hospital, Sorbonne University, AP‐HP Paris France
Luisa Brussino
Department of Medical Sciences University of Turin Turin Italy
Roland Buhl
Department of Pulmonary Medicine Mainz University Hospital Mainz Germany
José Antonio Castillo‐Vizuete
Pneumology Department Hospital Universitari Dexeus Barcelona Spain
Denis Charpin
Clinique Des Bronches, Allergie et Sommeil Hôpital Nord Marseille France
Niels H. Chavannes
Department of Public Health and Primary Care Leiden University Medical Centre Leiden the Netherlands
Marta Chełmińska
Department of Pulmonology and Allergology Medical University of Gdańsk Gdańsk Poland
Lei Cheng
Department of Allergology and Otorhinolaryngology The First Affiliated Hospital, Nanjing Medical University Nanjing China
Ekaterine Chkhartishvili
Allergist David Tvildiani Medical University Tbilisi Georgia
Seong H. Cho
University of South Florida College of Médicine, Division of Allergy‐Immunology, Department of Internal Medicine Tampa Florida USA
Herberto Jose Chong‐Neto
Associate Professor of Pediatrics, Division of Allergy and Immunology Federal University of Parana Curitiba Brazil
Deepa Choudhury
Paediatric Allergy Clinic, Department of Dermatology, Amersham Hospital NHS Hospital Trust Amersham UK
Derek K. Chu
Department of Health Research Methods, Evidence, and Impact & Department of Medicine McMaster University Hamilton Ontario Canada
Enrico Compalati
Scientific & Medical Department Lofarma S.p.A Milan Italy
Raquel Albuquerque Costa
MEDCIDS—Department of Community Medicine, Information and Health Decision Sciences, Faculty of Medicine University of Porto Porto Portugal
Olga Mariana Cunha
LAQV@REQUIMTE, Laboratory of Pharmacology, Department of Drug Sciences, Faculty of Pharmacy University of Porto Porto Portugal
Biljana Cvetkovski
Woolcock Institute of Medical Research Sydney Australia
Victoria Cardona‐Dahl
Allergy Section, Department of Internal Medicine Hospital Vall D'hebron Barcelona Spain
Gennaro D'Amato
Division of Respiratory and Allergic Diseases, High Specialty Hospital ‘A Cardarelli’, and Respiratory Allergy School of Specialization in Respiratory Diseases Federico II University of Naples Naples Italy
Janet Davies
Centre for Immunology and Infection Control, School of Biomedical Sciences, Faculty of Health Queensland University of Technology Brisbane Australia
Danilo Di Bona
University of Foggia Department of Medical and Surgical Science Foggia Italy
Sandra N. Gonzalez Diaz
Allergy and Clinical Immunology Centro Regional Hospital Universitario, Universidad Autónoma de Nuevo Leon Monterrey Mexico
Maria V. Dimou
Allergy Department 2nd Pediatric Clinic, University of Athens Athens Greece
Maria Doulaptsi
Department of Otorhinolaryngology, Head and Neck Surgery University of Crete, School of Medicine Heraklion Crete Greece
Renato Ferreira‐da‐Silva
MEDCIDS—Department of Community Medicine, Information and Health Decision Sciences, Faculty of Medicine University of Porto Porto Portugal
Radoslaw Gawlik
Department of Internal Diseases, Allergology and Clinical Immunology Medical University of Silesia in Katowice Katowice Poland
Mario Calvo‐Gil
Pediatrics Department Universidad Austral de Chile Valvidia Chile
Ozlem Goksel
Department of Pulmonary Medicine, Division of Immunology, Allergy and Asthma, Laboratory of Occupational and Environmental Respiratory Diseases, Faculty of Medicine Ege University, EgeSAM (Ege University Translational Pulmonary Research Center) Bornova Izmir Türkiye
Maximiliano R. Gómez
Faculty of Health Sciences Catholic University of Salta Salta Argentina
Maia Gotua
Center of Allergy and Immunology, and Georgian Academy of Allergy Asthma, and Clinical Immunology Tbilisi Georgia
Christos Grigoreas
Former President of the Hellenic Society of Allergology and Clinical Immunology, Department of Allergy and Clinical Immunology Air Force General Hospital Athens Greece
Ineta Grisle
Riga East University Hospital Riga Latvia
Maria Antonieta Guzman
Immunology and Allergy Division, Clinical Hospital University of Chile Santiago Chile
Rachel House Tan
Quality Use of Research Medicines Group Woolcock Institute of Medical Research Macquarie Park New South Wales Australia
Michael Hyland
Faculty of Health University of Plymouth Plymouth UK
Despo Ierodiakonou
Department of Primary Care and Population Health University of Nicosia Medical School Nicosia Cyprus
Aspasia Karavelia
Otolaryngology Department General Hospital of Kalamata Kalamata City Greece
Paul Keith
Division of Clinical Immunology and Allergy, Department of Medicine McMaster University Hamilton Ontario Canada
Marta Kisiel
Occupational and Environmental Medicine, Department of Medical Sciences Uppsala University Uppsala Sweden
Ilgim Vardaloglu Koyuncu
Bagcilar Research and Training Hospital Department of Chest Diseases Istanbul Turkey
Vicky Kritikos
Clinical Management Group, Woolcock Institute of Medical Research Macquarie University Sydney New South Wales Australia
Justyna Litynska
Evidence Prime Kraków Poland
Carlo Lombardi
Departmental Unit of Allergology Clinical Immunology & Pneumology, Istituto Ospedaliero Fondazione Poliambulanza Brescia Italy
Gilles Louis
Department of Public Health University of Liège Liège Belgium
Matteo Martini
Allergy Unit, Department of Internal Medicine University Hospital AOU Delle Marche Ancona Italy
Cem Meço
Department of Otorhinolaryngology, Head and Neck Surgery Ankara University Medical School Ankara Turkey
Eris Mesonjesi
Allergy & Clinical Immunology Department University Hospital Center “Mother Teresa” Tirana Albania
Florin Mihaltan
UMF‐University of Medicine and Pharmacy ‘Carol Davila’, Pneumology Department National Institute of Pneumology ‘Marius Nasta’ Bucharest Romania
Marcin Moniuszko
Department of Allergology and Internal Medicine Medical University of Bialystok Bialystok Poland
Robert N. Naclerio
Department of Otolaryngology‐Head and Neck Surgery Johns Hopkins University Baltimore Maryland USA
Kari C. Nadeau
Department of Environmental Health, Harvard TH Chan School of Public Health and Department of Medicine, Division of Allergy and Inflammation Beth Israel Deaconess Hospital Boston Massachusetts USA
Sophia Neisinger
Institute of Allergology Charité—Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt‐Universität Zu Berlin Berlin Germany
Markus Ollert
Department of Infection and Immunity Luxembourg Institute of Health Esch‐sur‐Alzette Luxembourg
Michal Ordak
Department of Pharmacotherapy and Pharmaceutical Care, Faculty of Pharmacy Medical University of Warsaw Warsaw Poland
Hae‐Sim Park
Department of Allergy and Clinical Immunology Ajou University School of Medicine Suwon Republic of Korea
Elena Parmelli
Asthma & Allergy Unit IRCCS Humanitas Research Hospital, Rozzano Milan Italy
Edgar Arturo Perdomo‐Flores
Otorhinolaryngology and Neck Surgery Unit San Juan de Dios National Hospital San Miguel El Salvador
Nhan Pham‐Thi
Ecole Polytechnique de Palaiseau Palaiseau France
Emmanuel Prokopakis
Department of Otorhinolaryngology, Head and Neck Surgery University of Crete, School of Medicine Heraklion Crete Greece
Inês Ribeiro‐Vaz
MEDCIDS—Department of Community Medicine, Information and Health Decision Sciences, Faculty of Medicine University of Porto Porto Portugal
Giovanni Rolla
Department of Medical Sciences University of Turin Turin Italy
Jan Romantowski
Department of Allergology Medical University of Gdansk Gdansk Poland
Philippe Rombaux
Department of Otorhinolaryngology Cliniques Universitaires Saint‐Luc Brussels Belgium
Philip W. Rouadi
Department of Otolaryngology‐Head and Neck Surgery Eye and Ear University Hospital Beirut Lebanon
Maia Rukhadze
Center Allergy & Immunology/Geomedi Teaching University Faculty of Medicine Tbilisi Georgia
Daiju Sakurai
Department of Otorhinolaryngology Yamanashi University Yamanashi Japan
Laila Salameh
Mohammed Bin Rashid University (MBRU) Dubai Health Dubai UAE
Faradiba Serpa Sarquis
Asthma Reference Center—School of Medicine of Santa Casa de Misericórdia of Vitória Espírito Santo Brazil
Elie Serrano
Department of Otorhinolaryngology and Head & Neck Surgery CHU Rangueil‐Larrey Toulouse France
Jane Da Silva
Allergy Service University Hospital Professor Polydoro Ernani de São Thiago (HU‐UFSC/EBSERH) Florianopolis Brazil
Michael Soyka
Otolaryngology‐HNS, University of Zurich University Hospital of Zurich Zurich Switzerland
Krzysztof Specjalski
Department of Allergology Medical University of Gdansk Gdansk Poland
Vesna Tomic‐Spiric
Clinic of Allergology and Immunology University Clinical Center of Serbia Belgrade Serbia
Katarina Stevanovic
Institute of Allergology Charité—Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt‐Universität Zu Berlin Berlin Germany
Abirami Subramaniam
Department of Respiratory Medicine, Medical Professorial Unit Tallaght University Hospital & Trinity College Dublin Ireland
Maria Do Ceu Teixeira
Dr Agostinho Neto University Hospital Praia Cabo Verde
Tuuli Thomander
MEDCIDS—Department of Community Medicine, Information and Health Decision Sciences, Faculty of Medicine University of Porto Porto Portugal
Martina Vachova
Department of Immunology and Allergology University Hospital and Faculty of Medicine in Pilsen Pilsen Czech Republic
Marianne van Hage
Department of Medicine Solna, Division of Immunology and Respiratory Medicine Karolinska Institutet Stockholm Sweden
Pakit Vichyanond
Samitivej Allergy Institute Bangkok Thailand
Martin Wagenmann
Department of Otorhinolaryngology Heinrich Heine University Düsseldorf, Medical Faculty and University Hospital Düsseldorf Düsseldorf Germany
Fanny Wai San Ko
The Chinese University of Hong Kong Department of Medicine and Therapeutics Hong Kong China
Pascal Werminghaus
ENT and Allergology Düsseldorf Germany
Paraskevi Vicky Xepapadaki
Allergy Department 2nd Pediatric Clinic, University of Athens Athens Greece
Yi‐Kui Xiang
Institute of Allergology Charité—Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt‐Universität Zu Berlin Berlin Germany
Qintai Yang
The Third Affiliated Hospital of sun Yat‐Sen University Guangzhou China
Daniela Rivero Yeverino
Servicio de Alergia e Inmunología clínica Hospital Universitario de Puebla Puebla México
Jaron Zuberbier
Department of Otorhinolaryngology Charité—Universitätsmedizin Berlin Berlin Germany
João A. Fonseca
MEDCIDS—Department of Community Medicine, Information and Health Decision Sciences, Faculty of Medicine University of Porto Porto Portugal
Abstract (eng)
Background
Allergic rhinitis (AR) impacts quality of life, work and school productivity. Over the last years, an important body of evidence resulting from mHealth data has led to a better understanding of AR. Such advances have motivated an EAACI-endorsed update of the Allergic Rhinitis and its Impact on Asthma (ARIA) guidelines (ARIA 2024–2025). This manuscript presents the ARIA 2024–2025 recommendations for intranasal treatments, one of the mainstays for AR management.
Methods
The ARIA 2024–2025 guideline panel issued recommendations following the Grading of Recommendations, Assessment, Development, and Evaluation (GRADE) evidence-to-decision framework. Several sources of evidence were used to inform panel judgments and recommendations, including systematic reviews, evaluation of mHealth and pharmacovigilance data, as well as a survey of experts on costs.
Results
Eleven guideline questions concerning intranasal treatments for AR were prioritized, leading to recommendations. Overall, these questions concern the choice between different classes of intranasal medications—most notably, intranasal corticosteroids (INCS), antihistamines (INAH), fixed combinations of INAH+INCS and decongestants—or between different individual medications within each class. Four questions had not been evaluated in previous ARIA guidelines, while for the other three there was a change in the strength or directionality of recommendations. Overall, recommendations point to the suggested use of INAH+INCS over INAH or INCS and INCS over INAH.
Conclusion
This ARIA 2024–2025 article supports patients, their caregivers, and healthcare professionals in choosing an intranasal treatment. However, decisions on AR treatment should consider the clinical variability of the disease, patients' values, and the affordability of medications.
Remark (eng)
Online Version of Record before inclusion in an issue
Keywords (eng)
Allergic RhinitisGuidelinesIntranasal AntihistaminesIntranasal Corticosteroids
Type (eng)
Language
[eng]
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Is in series
Title (eng)
Allergy
ISSN
0105-4538
Issued
2025
Number of pages
23
Publication
Wiley
Version type (eng)
Date issued
2025
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© 2025 The Author(s)
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