Title
Cdk6: At the interface of Rb and p53
Language
English
Description (en)
In cancer the activity of cyclin-dependent kinase 4-(CDK4) and cyclin-dependent kinase 6 (CDK6)-cyclin complexes are frequently altered with enhanced CDK6 expression found in hematopoietic malignancies. Our latest findings show a so far unknown role of Cdk6 during oncogene-induced stress and transformation. Therein Cdk6 antagonizes p53 responses and subsequently shapes the critical decision between survival and apoptosis in pre-leukemic cells.
DOI
10.1080/23723556.2018.1511206
Author of the digital object
Sofie Nebenführ (University of Veterinary Medicine Vienna)
Florian Belutti (University of Veterinary Medicine Vienna)
Veronika Sexl (University of Veterinary Medicine Vienna)
OpenAIRE Version Type
publishedVersion
Format
application/pdf
Size
991.2 kB
Licence Selected
CC BY-NC-ND 4.0 International
OpenAIRE Access Rights
openAccess
Type of publication
Article
additional allocation
Institut für Pharmakologie und Toxikologie
Name of Publication (de)
Molecular & Cellular Oncology
Pages or Volume
3 Seiten
Volume
5
Number
5
Publication Date
2018
Citable links
Persistent identifier
https://phaidra.vetmeduni.ac.at/o:58
Cite
DOI
https://doi.org/10.1080/23723556.2018.1511206
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Veterinärmedizinische Universität Wien (Vetmeduni) | Veterinärplatz 1 | 1210 Wien - Österreich | T
+43 1 25077 1414 | Web: vetmeduni.ac.at