Nebenführ, Sofie (University of Veterinary Medicine Vienna) Sofie Nebenführ Belutti, Florian (University of Veterinary Medicine Vienna) Florian Belutti Sexl, Veronika (University of Veterinary Medicine Vienna) Veronika Sexl 2018 In cancer the activity of cyclin-dependent kinase 4-(CDK4) and cyclin-dependent kinase 6 (CDK6)-cyclin complexes are frequently altered with enhanced CDK6 expression found in hematopoietic malignancies. Our latest findings show a so far unknown role of Cdk6 during oncogene-induced stress and transformation. Therein Cdk6 antagonizes p53 responses and subsequently shapes the critical decision between survival and apoptosis in pre-leukemic cells. PDFDocument en 2019-08-20T15:02:52.928Z 1014963 b application/pdf CC BY-NC-ND 4.0 International