https://phaidra.vetmeduni.ac.at/o:58 Cdk6: At the interface of Rb and p53 Nebenführ, Sofie Sofie Nebenführ University of Veterinary Medicine Vienna Belutti, Florian Florian Belutti 0000-0003-2095-4971 University of Veterinary Medicine Vienna Sexl, Veronika Veronika Sexl 0000-0001-9363-0412 University of Veterinary Medicine Vienna text open access eng In cancer the activity of cyclin-dependent kinase 4-(CDK4) and cyclin-dependent kinase 6 (CDK6)-cyclin complexes are frequently altered with enhanced CDK6 expression found in hematopoietic malignancies. Our latest findings show a so far unknown role of Cdk6 during oncogene-induced stress and transformation. Therein Cdk6 antagonizes p53 responses and subsequently shapes the critical decision between survival and apoptosis in pre-leukemic cells. http://creativecommons.org/licenses/by-nc-nd/4.0/ https://phaidra.vetmeduni.ac.at/api/object/o:58/download 10.1080/23723556.2018.1511206 https://phaidra.vetmeduni.ac.at/o:605 application/pdf Molecular & Cellular Oncology 5(5) (2018) VoR Molecular & Cellular Oncology 5 5 991.17 kB 2018