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Title (en)
Empirical and model-based evidence for a negligible role of cattle in peste des petits ruminants virus transmission and eradication
Language
English
Description (en)
Peste des petits ruminants virus (PPRV) is a multi-host pathogen with sheep and goats as main hosts. To investigate the role of cattle in the epidemiology of PPR, we simulated conditions similar to East African zero-grazing husbandry practices in a series of trials with local Zebu cattle (Bos taurus indicus) co-housed with goats (Capra aegagrus hircus). Furthermore, we developed a mathematical model to assess the impact of PPRV-transmission from cattle to goats. Of the 32 cattle intranasally infected with the locally endemic lineage IV strain PPRV/Ethiopia/Habru/2014 none transmitted PPRV to 32 co-housed goats. However, these cattle or cattle co-housed with PPRV-infected goats seroconverted. The results confirm previous studies that cattle currently play a negligible role in PPRV-transmission and small ruminant vaccination is sufficient for eradication. However, the possible emergence of PPRV strains more virulent for cattle may impact eradication. Therefore, continued monitoring of PPRV circulation and evolution is recommended.
Keywords (en)
Animals; Peste-des-Petits-Ruminants transmission virology epidemiology; Cattle; Peste-des-petits-ruminants virus immunology physiology; Goats virology; Goat Diseases virology transmission; Cattle diseases transmission virology epidemiology; Disease eradication methods
DOI
10.1038/s42003-024-06619-2
Author of the digital object
Catherine M. Herzog  (Pennsylvania State University)
Vivek Kapur  (Pennsylvania State University)
Michael D. Baron  (The Pirbright Institute)
Ottar N. Bjørnstad  (Pennsylvania State University)
Nick Juleff  (Bill & Melinda Gates Foundation)
Solomon Gebre  (Animal Health Institute)
Tesfaye Rufael Chibssa  (Animal Health Institute)
Mesfin Sahle Forza  (Animal Health Institute)
Joram Buza  (Nelson Mandela African Institution of Science and Technology)
Hagos Asgedom  (Animal Health Institute)
Peter J. Hudson  (Pennsylvania State University)
Isabella M. Cattadori  (Pennsylvania State University)
Andrew R. Peters  (University of Edinburgh)
Dalan Bailey  (The Pirbright Institute)
Sarah Cleaveland  (University of Glasgow)
Brian J. Willett  (University of Glasgow)
Claudia Schulz  (University of Veterinary Medicine Vienna)
Menbere Kidane  (Animal Health Institute)
Abde Aliy Mohammed  (Animal Health Institute)
Redeat Belaineh  (Animal Health Institute)
Dereje Shegu  (Animal Health Institute)
Fasil Aklilu  (Animal Health Institute )
Demeke Sibhatu  (Animal Health Institute)
Format
application/pdf
Size
2.1 MB
Licence Selected
CC BY 4.0 International
Type of publication
Article
Name of Publication (en)
Communications Biology
Pages or Volume
10
Volume
7
Number
1
Publisher
Nature Portfolio
Publication Date
2024