phaidra.vetmeduni.ac.at o:3531 DOI 10.1038/s42003-024-06619-2 Empirical and model-based evidence for a negligible role of cattle in peste des petits ruminants virus transmission and eradication Peste des petits ruminants virus (PPRV) is a multi-host pathogen with sheep and goats as main hosts. To investigate the role of cattle in the epidemiology of PPR, we simulated conditions similar to East African zero-grazing husbandry practices in a series of trials with local Zebu cattle (Bos taurus indicus) co-housed with goats (Capra aegagrus hircus). Furthermore, we developed a mathematical model to assess the impact of PPRV-transmission from cattle to goats. Of the 32 cattle intranasally infected with the locally endemic lineage IV strain PPRV/Ethiopia/Habru/2014 none transmitted PPRV to 32 co-housed goats. However, these cattle or cattle co-housed with PPRV-infected goats seroconverted. The results confirm previous studies that cattle currently play a negligible role in PPRV-transmission and small ruminant vaccination is sufficient for eradication. However, the possible emergence of PPRV strains more virulent for cattle may impact eradication. Therefore, continued monitoring of PPRV circulation and evolution is recommended. eng Animals; Peste-des-Petits-Ruminants transmission virology epidemiology; Cattle; Peste-des-petits-ruminants virus immunology physiology; Goats virology; Goat Diseases virology transmission; Cattle diseases transmission virology epidemiology; Disease eradication methods 2024-10-04T10:35:12.344Z LOMv1.0 Author BEGIN:VCARD VERSION:3.0 N:Herzog;Catherine M.; FN:Catherine M. Herzog X-ORCID:https://orcid.org/0000-0003-3021-888X END:VCARD BEGIN:VCARD VERSION:3.0 N:Kapur;Vivek; FN:Vivek Kapur X-ORCID:https://orcid.org/0000-0002-9648-0138 END:VCARD BEGIN:VCARD VERSION:3.0 N:Baron;Michael D.; FN:Michael D. Baron END:VCARD BEGIN:VCARD VERSION:3.0 N:Bjørnstad;Ottar N.; FN:Ottar N. Bjørnstad X-ORCID:https://orcid.org/0000-0002-1158-3753 END:VCARD BEGIN:VCARD VERSION:3.0 N:Juleff;Nick; FN:Nick Juleff X-ORCID:https://orcid.org/0000-0002-0402-9658 END:VCARD BEGIN:VCARD VERSION:3.0 N:Gebre;Solomon; FN:Solomon Gebre END:VCARD BEGIN:VCARD VERSION:3.0 N:Chibssa;Tesfaye Rufael; FN:Tesfaye Rufael Chibssa END:VCARD BEGIN:VCARD VERSION:3.0 N:Forza;Mesfin Sahle; FN:Mesfin Sahle Forza END:VCARD BEGIN:VCARD VERSION:3.0 N:Buza;Joram; FN:Joram Buza END:VCARD BEGIN:VCARD VERSION:3.0 N:Asgedom;Hagos; FN:Hagos Asgedom END:VCARD BEGIN:VCARD VERSION:3.0 N:Hudson;Peter J.; FN:Peter J. Hudson X-ORCID:https://orcid.org/0000-0003-0468-3403 END:VCARD BEGIN:VCARD VERSION:3.0 N:Cattadori;Isabella M.; FN:Isabella M. Cattadori X-ORCID:https://orcid.org/0000-0001-6618-316X END:VCARD BEGIN:VCARD VERSION:3.0 N:Peters;Andrew R.; FN:Andrew R. Peters END:VCARD BEGIN:VCARD VERSION:3.0 N:Bailey;Dalan; FN:Dalan Bailey X-ORCID:https://orcid.org/0000-0002-5640-2266 END:VCARD BEGIN:VCARD VERSION:3.0 N:Cleaveland;Sarah; FN:Sarah Cleaveland X-ORCID:https://orcid.org/0000-0002-0456-0959 END:VCARD BEGIN:VCARD VERSION:3.0 N:Willett;Brian J.; FN:Brian J. Willett X-ORCID:https://orcid.org/0000-0001-8912-3266 END:VCARD BEGIN:VCARD VERSION:3.0 N:Schulz;Claudia; FN:Claudia Schulz X-ORCID:https://orcid.org/0000-0003-4614-618X END:VCARD BEGIN:VCARD VERSION:3.0 N:Kidane;Menbere; FN:Menbere Kidane END:VCARD BEGIN:VCARD VERSION:3.0 N:Mohammed;Abde Aliy; FN:Abde Aliy Mohammed END:VCARD BEGIN:VCARD VERSION:3.0 N:Belaineh;Redeat; FN:Redeat Belaineh END:VCARD BEGIN:VCARD VERSION:3.0 N:Shegu;Dereje; FN:Dereje Shegu X-ORCID:https://orcid.org/0000-0002-2907-6151 END:VCARD BEGIN:VCARD VERSION:3.0 N:Aklilu;Fasil; FN:Fasil Aklilu X-ORCID:https://orcid.org/0000-0001-9846-0301 END:VCARD BEGIN:VCARD VERSION:3.0 N:Sibhatu;Demeke; FN:Demeke Sibhatu END:VCARD https://w3id.org/kim/hcrt/scheme https://w3id.org/kim/hcrt/text Textdokument Text LOMv1.0 yes https://creativecommons.org/licenses/by/4.0 application/pdf 2156692 https://phaidra.vetmeduni.ac.at/o:3531 https://phaidra.vetmeduni.ac.at/api/object/o:3531/thumbnail LOMv1.0 discipline