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Title (en)
The World of Organoids: Gastrointestinal Disease Modelling in the Age of 3R and One Health with Specific Relevance to Dogs and Cats
Language
English
Description (en)
One Health describes the importance of considering humans, animals, and the environment in health research. One Health and the 3R concept, i.e., the replacement, reduction, and refinement of animal experimentation, shape today's research more and more. The development of organoids from many different organs and animals led to the development of highly sophisticated model systems trying to replace animal experiments. Organoids may be used for disease modelling in various ways elucidating the manifold host-pathogen interactions. This review provides an overview of disease modelling approaches using organoids of different kinds with a special focus on animal organoids and gastrointestinal diseases. We also provide an outlook on how the research field of organoids might develop in the coming years and what opportunities organoids hold for in-depth disease modelling and therapeutic interventions.
Keywords (en)
Stem-Cells; In-Vitro; Clostridioides-Difficile; Intestinal Organoids; Culture-Systems; Human Colon; Canine; Mouse; Liver; Establishment
DOI
10.3390/ani12182461
Author of the digital object
Georg Csukovich  (University of Veterinary Medicine Vienna)
Iwan Anton Burgener  (University of Veterinary Medicine Vienna)
Barbara Pratscher  (University of Veterinary Medicine Vienna)
Format
application/pdf
Size
366.3 kB
Licence Selected
CC BY 4.0 International
Type of publication
Article
Name of Publication (en)
Animals
Pages or Volume
16
Volume
12
Number
18
Publisher
MDPI
Publication Date
2022