phaidra.vetmeduni.ac.at o:2082 DOI 10.3390/ani12182461 The World of Organoids: Gastrointestinal Disease Modelling in the Age of 3R and One Health with Specific Relevance to Dogs and Cats One Health describes the importance of considering humans, animals, and the environment in health research. One Health and the 3R concept, i.e., the replacement, reduction, and refinement of animal experimentation, shape today's research more and more. The development of organoids from many different organs and animals led to the development of highly sophisticated model systems trying to replace animal experiments. Organoids may be used for disease modelling in various ways elucidating the manifold host-pathogen interactions. This review provides an overview of disease modelling approaches using organoids of different kinds with a special focus on animal organoids and gastrointestinal diseases. We also provide an outlook on how the research field of organoids might develop in the coming years and what opportunities organoids hold for in-depth disease modelling and therapeutic interventions. eng Stem-Cells; In-Vitro; Clostridioides-Difficile; Intestinal Organoids; Culture-Systems; Human Colon; Canine; Mouse; Liver; Establishment 2023-09-08T11:28:12.138Z LOMv1.0 Author BEGIN:VCARD VERSION:3.0 N:Csukovich;Georg; FN:Georg Csukovich X-ORCID:https://orcid.org/0000-0001-5615-666X END:VCARD BEGIN:VCARD VERSION:3.0 N:Burgener;Iwan Anton; FN:Iwan Anton Burgener X-ORCID:https://orcid.org/0000-0002-8516-0040 END:VCARD BEGIN:VCARD VERSION:3.0 N:Pratscher;Barbara; FN:Barbara Pratscher X-ORCID:https://orcid.org/0000-0001-5291-1365 END:VCARD https://w3id.org/kim/hcrt/scheme https://w3id.org/kim/hcrt/text Textdokument Text LOMv1.0 yes https://creativecommons.org/licenses/by/4.0 application/pdf 375123 https://phaidra.vetmeduni.ac.at/o:2082 https://phaidra.vetmeduni.ac.at/api/object/o:2082/thumbnail LOMv1.0 discipline