Title (eng)

Cdk6: At the interface of Rb and p53

Author

Sofie Nebenführ   University of Veterinary Medicine Vienna

Florian Belutti   University of Veterinary Medicine Vienna

Veronika Sexl   University of Veterinary Medicine Vienna

Description (eng)

In cancer the activity of cyclin-dependent kinase 4-(CDK4) and cyclin-dependent kinase 6 (CDK6)-cyclin complexes are frequently altered with enhanced CDK6 expression found in hematopoietic malignancies. Our latest findings show a so far unknown role of Cdk6 during oncogene-induced stress and transformation. Therein Cdk6 antagonizes p53 responses and subsequently shapes the critical decision between survival and apoptosis in pre-leukemic cells.

Object languages

English

Date

2018

Rights

This work is licensed under a
CC BY-NC-ND 4.0 - Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License.

CC BY-NC-ND 4.0 International

http://creativecommons.org/licenses/by-nc-nd/4.0/

openAccess

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