Titel (eng)

Cdk6: At the interface of Rb and p53

Autor*in

Sofie Nebenführ   University of Veterinary Medicine Vienna

Florian Belutti   University of Veterinary Medicine Vienna

Veronika Sexl   University of Veterinary Medicine Vienna

Beschreibung (eng)

In cancer the activity of cyclin-dependent kinase 4-(CDK4) and cyclin-dependent kinase 6 (CDK6)-cyclin complexes are frequently altered with enhanced CDK6 expression found in hematopoietic malignancies. Our latest findings show a so far unknown role of Cdk6 during oncogene-induced stress and transformation. Therein Cdk6 antagonizes p53 responses and subsequently shapes the critical decision between survival and apoptosis in pre-leukemic cells.

Sprache des Objekts

Englisch

Datum

2018

Rechte

Dieses Werk bzw. dieser Inhalt steht unter einer
CC BY-NC-ND 4.0 - Creative Commons Namensnennung - Nicht-kommerziell - Keine Bearbeitungen 4.0 International Lizenz.

CC BY-NC-ND 4.0 International

http://creativecommons.org/licenses/by-nc-nd/4.0/

openAccess

Mitglied in der/den Collection(s) (1)