Molecular Signatures and Functional Pathways of Human Monocytes and Macrophages in Allergy: An <scp>EAACI AllergoOncology</scp> Scoping Review
Title (eng)
Molecular Signatures and Functional Pathways of Human Monocytes and Macrophages in Allergy: An <scp>EAACI AllergoOncology</scp> Scoping Review
Author
Rodolfo Bianchini
Department of Biological Sciences and Pathobiology, University of Veterinary Medicine of Vienna, Vienna, Austria
Vanda Pick
Rebecca Adams
Isabel Adoración Martín‐Antoniano
Hanna Mayerhofer
Messerli Research Institute of Human Animal Interactions, Department of Interdisciplinary Life Sciences, University of Veterinary Medicine Vienna, Vienna, Austria
Alessandro Michelucci
Giuseppe Nocentini
Gabriel Osborn
Erika Jensen‐Jarolim
Messerli Research Institute of Human Animal Interactions, Department of Interdisciplinary Life Sciences, University of Veterinary Medicine Vienna, Vienna, Austria
Abstract (eng)
AllergoOncology explores the intersection of allergic diseases and cancer, focusing on shared immune mechanisms. While monocytes and macrophages are extensively studied in cancer, their roles in allergic diseases remain underexplored. To address this gap, we conducted a scoping review to systematically characterize the molecular landscape and related pathways of human monocytes and macrophages in allergy. An automated search of PubMed and Web of Science databases retrieved 4668 unique articles, which were manually curated based on predefined inclusion and exclusion criteria, yielding 138 eligible studies. From these, we identified 451 molecules associated with monocyte and macrophage responses across allergic disorders. Data analyses revealed a research bias towards blood-derived monocytes, underrepresentation of tissue-resident macrophages, and limited inclusion of miRNAs. Semantic similarity and pathway enrichment analyses highlighted a common molecular signature across major allergic disorders, with consistent enrichment in interleukin signaling and immune activation pathways. To enhance reproducibility and translational utility for researchers and clinicians, we developed ALO•HA, a web application for interactive data exploration. This overview of monocyte and macrophage molecular responses in human allergy underscores the need for integrative, human-focused approaches to better define their roles, and to guide future therapeutic strategies in allergic diseases and at the interface with oncology.
Keywords (eng)
AllergoOncologyData-driven BioinformaticsAllergyMacrophagesMonocytes
Type (eng)
Language
[eng]
Persistent identifier
Is in series
Title (eng)
Allergy
Volume
80
Issue
10
ISSN
0105-4538
Issued
2025
Number of pages
16
Publication
Wiley
Version type (eng)
Date issued
2025
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© 2025 The Author(s)
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https://phaidra.vetmeduni.ac.at/o:5051 - Other links and identifiers
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- RightsLicenseRights statement© 2025 The Author(s)
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