Rodolfo Bianchini (Department of Biological Sciences and Pathobiology, University of Veterinary Medicine of Vienna, Vienna, Austria) Rodolfo Bianchini Andrea Escolar‐Peña Andrea Escolar‐Peña Vanda Pick Vanda Pick Aurélie Poli Aurélie Poli Rebecca Adams Rebecca Adams José Basilio José Basilio Luigi Cari Luigi Cari Jitesh Chauhan Jitesh Chauhan Tomás Chivato Tomás Chivato Leticia de las Vecillas Leticia de las Vecillas María Isabel Delgado‐Dolset María Isabel Delgado‐Dolset Maria M. Escribese Maria M. Escribese Melanie Grandits Melanie Grandits Heather J. Bax Heather J. Bax Isabel Adoración Martín‐Antoniano Isabel Adoración Martín‐Antoniano Leticia Martín‐Cruz Leticia Martín‐Cruz Hanna Mayerhofer (Messerli Research Institute of Human Animal Interactions, Department of Interdisciplinary Life Sciences, University of Veterinary Medicine Vienna, Vienna, Austria) Hanna Mayerhofer Alessandro Michelucci Alessandro Michelucci Giuseppe Nocentini Giuseppe Nocentini Gabriel Osborn Gabriel Osborn Carmela Pablo‐Torres Carmela Pablo‐Torres Oscar Palomares Oscar Palomares Mariona Pascal Mariona Pascal Urszula Radzikowska Urszula Radzikowska Nataliya Rohr‐Udilova Nataliya Rohr‐Udilova Milena Sokolowska Milena Sokolowska Christoph Bergmann Christoph Bergmann Erika Jensen‐Jarolim (Messerli Research Institute of Human Animal Interactions, Department of Interdisciplinary Life Sciences, University of Veterinary Medicine Vienna, Vienna, Austria) Erika Jensen‐Jarolim Sophia N. Karagiannis Sophia N. Karagiannis Rocio Rebollido‐Rios Rocio Rebollido‐Rios Elena Izquierdo Elena Izquierdo Wiley 2025 AllergoOncology explores the intersection of allergic diseases and cancer, focusing on shared immune mechanisms. While monocytes and macrophages are extensively studied in cancer, their roles in allergic diseases remain underexplored. To address this gap, we conducted a scoping review to systematically characterize the molecular landscape and related pathways of human monocytes and macrophages in allergy. An automated search of PubMed and Web of Science databases retrieved 4668 unique articles, which were manually curated based on predefined inclusion and exclusion criteria, yielding 138 eligible studies. From these, we identified 451 molecules associated with monocyte and macrophage responses across allergic disorders. Data analyses revealed a research bias towards blood-derived monocytes, underrepresentation of tissue-resident macrophages, and limited inclusion of miRNAs. Semantic similarity and pathway enrichment analyses highlighted a common molecular signature across major allergic disorders, with consistent enrichment in interleukin signaling and immune activation pathways. To enhance reproducibility and translational utility for researchers and clinicians, we developed ALO•HA, a web application for interactive data exploration. This overview of monocyte and macrophage molecular responses in human allergy underscores the need for integrative, human-focused approaches to better define their roles, and to guide future therapeutic strategies in allergic diseases and at the interface with oncology. PDFDocument eng 2026-04-15T07:52:39.413415Z 2025 AllergoOncology Data-driven Bioinformatics Allergy Macrophages Monocytes 4587507 b application/pdf http://creativecommons.org/licenses/by-nc/4.0/