https://phaidra.vetmeduni.ac.at/o:5051 Molecular Signatures and Functional Pathways of Human Monocytes and Macrophages in Allergy: An <scp>EAACI AllergoOncology</scp> Scoping Review Bianchini, Rodolfo Rodolfo Bianchini 0000-0003-0351-6937 Department of Biological Sciences and Pathobiology, University of Veterinary Medicine of Vienna, Vienna, Austria Escolar‐Peña, Andrea Andrea Escolar‐Peña 0009-0008-8197-6107 Pick, Vanda Vanda Pick Poli, Aurélie Aurélie Poli 0000-0002-7986-0761 Adams, Rebecca Rebecca Adams Basilio, José José Basilio 0000-0001-7380-2942 Cari, Luigi Luigi Cari 0000-0003-0698-3872 Chauhan, Jitesh Jitesh Chauhan 0000-0002-3968-9234 Chivato, Tomás Tomás Chivato 0000-0002-5403-0964 Vecillas, Leticia de las Leticia de las Vecillas 0000-0003-4969-5678 Delgado‐Dolset, María Isabel María Isabel Delgado‐Dolset 0000-0001-7924-5454 Escribese, Maria M. Maria M. Escribese 0000-0001-5057-5150 Grandits, Melanie Melanie Grandits 0000-0001-8143-8298 Bax, Heather J. Heather J. Bax 0000-0003-0432-4160 Martín‐Antoniano, Isabel Adoración Isabel Adoración Martín‐Antoniano Martín‐Cruz, Leticia Leticia Martín‐Cruz 0000-0002-2546-1183 Mayerhofer, Hanna Hanna Mayerhofer 0000-0001-7973-2092 Messerli Research Institute of Human Animal Interactions, Department of Interdisciplinary Life Sciences, University of Veterinary Medicine Vienna, Vienna, Austria Michelucci, Alessandro Alessandro Michelucci Nocentini, Giuseppe Giuseppe Nocentini Osborn, Gabriel Gabriel Osborn Pablo‐Torres, Carmela Carmela Pablo‐Torres 0000-0003-2861-5763 Palomares, Oscar Oscar Palomares 0000-0003-4516-0369 Pascal, Mariona Mariona Pascal 0000-0003-0549-9720 Radzikowska, Urszula Urszula Radzikowska 0000-0002-7341-9764 Rohr‐Udilova, Nataliya Nataliya Rohr‐Udilova 0000-0003-2432-3632 Sokolowska, Milena Milena Sokolowska 0000-0001-9710-6685 Bergmann, Christoph Christoph Bergmann 0000-0002-2076-8813 Jensen‐Jarolim, Erika Erika Jensen‐Jarolim 0000-0003-4019-5765 Messerli Research Institute of Human Animal Interactions, Department of Interdisciplinary Life Sciences, University of Veterinary Medicine Vienna, Vienna, Austria Karagiannis, Sophia N. Sophia N. Karagiannis 0000-0002-4100-7810 Rebollido‐Rios, Rocio Rocio Rebollido‐Rios 0000-0002-8910-867X Izquierdo, Elena Elena Izquierdo 0000-0002-3355-2798 Wiley journal article open access eng AllergoOncology explores the intersection of allergic diseases and cancer, focusing on shared immune mechanisms. While monocytes and macrophages are extensively studied in cancer, their roles in allergic diseases remain underexplored. To address this gap, we conducted a scoping review to systematically characterize the molecular landscape and related pathways of human monocytes and macrophages in allergy. An automated search of PubMed and Web of Science databases retrieved 4668 unique articles, which were manually curated based on predefined inclusion and exclusion criteria, yielding 138 eligible studies. From these, we identified 451 molecules associated with monocyte and macrophage responses across allergic disorders. Data analyses revealed a research bias towards blood-derived monocytes, underrepresentation of tissue-resident macrophages, and limited inclusion of miRNAs. Semantic similarity and pathway enrichment analyses highlighted a common molecular signature across major allergic disorders, with consistent enrichment in interleukin signaling and immune activation pathways. To enhance reproducibility and translational utility for researchers and clinicians, we developed ALO•HA, a web application for interactive data exploration. This overview of monocyte and macrophage molecular responses in human allergy underscores the need for integrative, human-focused approaches to better define their roles, and to guide future therapeutic strategies in allergic diseases and at the interface with oncology. AllergoOncology Data-driven Bioinformatics Allergy Macrophages Monocytes http://creativecommons.org/licenses/by-nc/4.0/ https://phaidra.vetmeduni.ac.at/api/object/o:5051/download 10.1111/all.16672 https://phaidra.vetmeduni.ac.at/o:605 application/pdf Allergy issn:0105-4538 VoR Allergy 80 10 4.37 MB 2025