phaidra.vetmeduni.ac.at o:5051 DOI 10.1111/all.16672 Molecular Signatures and Functional Pathways of Human Monocytes and Macrophages in Allergy: An <scp>EAACI AllergoOncology</scp> Scoping Review AllergoOncology explores the intersection of allergic diseases and cancer, focusing on shared immune mechanisms. While monocytes and macrophages are extensively studied in cancer, their roles in allergic diseases remain underexplored. To address this gap, we conducted a scoping review to systematically characterize the molecular landscape and related pathways of human monocytes and macrophages in allergy. An automated search of PubMed and Web of Science databases retrieved 4668 unique articles, which were manually curated based on predefined inclusion and exclusion criteria, yielding 138 eligible studies. From these, we identified 451 molecules associated with monocyte and macrophage responses across allergic disorders. Data analyses revealed a research bias towards blood-derived monocytes, underrepresentation of tissue-resident macrophages, and limited inclusion of miRNAs. Semantic similarity and pathway enrichment analyses highlighted a common molecular signature across major allergic disorders, with consistent enrichment in interleukin signaling and immune activation pathways. To enhance reproducibility and translational utility for researchers and clinicians, we developed ALO•HA, a web application for interactive data exploration. This overview of monocyte and macrophage molecular responses in human allergy underscores the need for integrative, human-focused approaches to better define their roles, and to guide future therapeutic strategies in allergic diseases and at the interface with oncology. eng AllergoOncology Data-driven Bioinformatics Allergy Macrophages Monocytes 2026-04-15T07:52:39.735Z LOMv1.0 Author BEGIN:VCARD VERSION:3.0 N:Bianchini;Rodolfo; FN:Rodolfo Bianchini X-ORCID:https://orcid.org/0000-0003-0351-6937 END:VCARD BEGIN:VCARD VERSION:3.0 N:Escolar‐Peña;Andrea; FN:Andrea Escolar‐Peña X-ORCID:https://orcid.org/0009-0008-8197-6107 END:VCARD BEGIN:VCARD VERSION:3.0 N:Pick;Vanda; FN:Vanda Pick END:VCARD BEGIN:VCARD VERSION:3.0 N:Poli;Aurélie; FN:Aurélie Poli X-ORCID:https://orcid.org/0000-0002-7986-0761 END:VCARD BEGIN:VCARD VERSION:3.0 N:Adams;Rebecca; FN:Rebecca Adams END:VCARD BEGIN:VCARD VERSION:3.0 N:Basilio;José; FN:José Basilio X-ORCID:https://orcid.org/0000-0001-7380-2942 END:VCARD BEGIN:VCARD VERSION:3.0 N:Cari;Luigi; FN:Luigi Cari X-ORCID:https://orcid.org/0000-0003-0698-3872 END:VCARD BEGIN:VCARD VERSION:3.0 N:Chauhan;Jitesh; FN:Jitesh Chauhan X-ORCID:https://orcid.org/0000-0002-3968-9234 END:VCARD BEGIN:VCARD VERSION:3.0 N:Chivato;Tomás; FN:Tomás Chivato X-ORCID:https://orcid.org/0000-0002-5403-0964 END:VCARD BEGIN:VCARD VERSION:3.0 N:Vecillas;Leticia de las; FN:Leticia de las Vecillas X-ORCID:https://orcid.org/0000-0003-4969-5678 END:VCARD BEGIN:VCARD VERSION:3.0 N:Delgado‐Dolset;María Isabel; FN:María Isabel Delgado‐Dolset X-ORCID:https://orcid.org/0000-0001-7924-5454 END:VCARD BEGIN:VCARD VERSION:3.0 N:Escribese;Maria M.; FN:Maria M. Escribese X-ORCID:https://orcid.org/0000-0001-5057-5150 END:VCARD BEGIN:VCARD VERSION:3.0 N:Grandits;Melanie; FN:Melanie Grandits X-ORCID:https://orcid.org/0000-0001-8143-8298 END:VCARD BEGIN:VCARD VERSION:3.0 N:Bax;Heather J.; FN:Heather J. Bax X-ORCID:https://orcid.org/0000-0003-0432-4160 END:VCARD BEGIN:VCARD VERSION:3.0 N:Martín‐Antoniano;Isabel Adoración; FN:Isabel Adoración Martín‐Antoniano END:VCARD BEGIN:VCARD VERSION:3.0 N:Martín‐Cruz;Leticia; FN:Leticia Martín‐Cruz X-ORCID:https://orcid.org/0000-0002-2546-1183 END:VCARD BEGIN:VCARD VERSION:3.0 N:Mayerhofer;Hanna; FN:Hanna Mayerhofer X-ORCID:https://orcid.org/0000-0001-7973-2092 END:VCARD BEGIN:VCARD VERSION:3.0 N:Michelucci;Alessandro; FN:Alessandro Michelucci END:VCARD BEGIN:VCARD VERSION:3.0 N:Nocentini;Giuseppe; FN:Giuseppe Nocentini END:VCARD BEGIN:VCARD VERSION:3.0 N:Osborn;Gabriel; FN:Gabriel Osborn END:VCARD BEGIN:VCARD VERSION:3.0 N:Pablo‐Torres;Carmela; FN:Carmela Pablo‐Torres X-ORCID:https://orcid.org/0000-0003-2861-5763 END:VCARD BEGIN:VCARD VERSION:3.0 N:Palomares;Oscar; FN:Oscar Palomares X-ORCID:https://orcid.org/0000-0003-4516-0369 END:VCARD BEGIN:VCARD VERSION:3.0 N:Pascal;Mariona; FN:Mariona Pascal X-ORCID:https://orcid.org/0000-0003-0549-9720 END:VCARD BEGIN:VCARD VERSION:3.0 N:Radzikowska;Urszula; FN:Urszula Radzikowska X-ORCID:https://orcid.org/0000-0002-7341-9764 END:VCARD BEGIN:VCARD VERSION:3.0 N:Rohr‐Udilova;Nataliya; FN:Nataliya Rohr‐Udilova X-ORCID:https://orcid.org/0000-0003-2432-3632 END:VCARD BEGIN:VCARD VERSION:3.0 N:Sokolowska;Milena; FN:Milena Sokolowska X-ORCID:https://orcid.org/0000-0001-9710-6685 END:VCARD BEGIN:VCARD VERSION:3.0 N:Bergmann;Christoph; FN:Christoph Bergmann X-ORCID:https://orcid.org/0000-0002-2076-8813 END:VCARD BEGIN:VCARD VERSION:3.0 N:Jensen‐Jarolim;Erika; FN:Erika Jensen‐Jarolim X-ORCID:https://orcid.org/0000-0003-4019-5765 END:VCARD BEGIN:VCARD VERSION:3.0 N:Karagiannis;Sophia N.; FN:Sophia N. Karagiannis X-ORCID:https://orcid.org/0000-0002-4100-7810 END:VCARD BEGIN:VCARD VERSION:3.0 N:Rebollido‐Rios;Rocio; FN:Rocio Rebollido‐Rios X-ORCID:https://orcid.org/0000-0002-8910-867X END:VCARD BEGIN:VCARD VERSION:3.0 N:Izquierdo;Elena; FN:Elena Izquierdo X-ORCID:https://orcid.org/0000-0002-3355-2798 END:VCARD https://w3id.org/kim/hcrt/scheme https://w3id.org/kim/hcrt/text Textdokument Text LOMv1.0 yes https://creativecommons.org/licenses/by-nc/4.0 application/pdf 4587507 https://phaidra.vetmeduni.ac.at/o:5051 https://phaidra.vetmeduni.ac.at/api/object/o:5051/thumbnail LOMv1.0 discipline