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Equine papillomavirus type 2-associated, carcinomatous lesions of the penis and laryngopharynx of an elderly Icelandic horse gelding
University of Veterinary Medicine Vienna
Antonia Geyer University of Veterinary Medicine Vienna
Christoph Jindra University of Veterinary Medicine Vienna
University of Veterinary Medicine Vienna
University of Veterinary Medicine Vienna
Wiley
A 28-year-old Icelandic horse gelding was presented with a laryngopharyngeal squamous cell carcinoma. The gelding had been treated for penile carcinoma in situ with a partial phallectomy 2 years earlier. Polymerase chain reaction of tumour DNA and subsequent amplicon sequencing revealed that the equine papillomavirus type 2 E6 oncogene sequences of both lesions were identical. There is strong evidence that equine papillomavirus type 2 is causally associated with genital squamous cell carcinomas and precancerous lesions. Recent reports indicate that equine papillomavirus type 2 might also play an active role in the pathogenesis of approximately 20% of equine squamous cell carcinomas in the oronasal, pharyngeal and laryngeal regions. To the authors' knowledge, this is the first report of a horse consecutively developing a penile carcinoma in situ and a laryngopharyngeal squamous cell carcinoma that were apparently induced by the same equine papillomavirus type 2 variant. Possible equine papillomavirus type 2 infection pathways in this horse and the importance of early detection of lesions are discussed in this context.
English
2022
This work is licensed under a
CC BY-NC-ND 4.0 - Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License.
CC BY-NC-ND 4.0 International
http://creativecommons.org/licenses/by-nc-nd/4.0/
Squamous-Cell Carcinoma; Healthy Skin; Ecpv2; Dna; Prevalence; Amputation; Neoplasia; Proposal; Tumors