o:3473 Equine papillomavirus type 2-associated, carcinomatous lesions of the penis and laryngopharynx of an elderly Icelandic horse gelding en A 28-year-old Icelandic horse gelding was presented with a laryngopharyngeal squamous cell carcinoma. The gelding had been treated for penile carcinoma in situ with a partial phallectomy 2 years earlier. Polymerase chain reaction of tumour DNA and subsequent amplicon sequencing revealed that the equine papillomavirus type 2 E6 oncogene sequences of both lesions were identical. There is strong evidence that equine papillomavirus type 2 is causally associated with genital squamous cell carcinomas and precancerous lesions. Recent reports indicate that equine papillomavirus type 2 might also play an active role in the pathogenesis of approximately 20% of equine squamous cell carcinomas in the oronasal, pharyngeal and laryngeal regions. To the authors' knowledge, this is the first report of a horse consecutively developing a penile carcinoma in situ and a laryngopharyngeal squamous cell carcinoma that were apparently induced by the same equine papillomavirus type 2 variant. Possible equine papillomavirus type 2 infection pathways in this horse and the importance of early detection of lesions are discussed in this context. Squamous-Cell Carcinoma; Healthy Skin; Ecpv2; Dna; Prevalence; Amputation; Neoplasia; Proposal; Tumors 1552099 10.1002/vrc2.508 2024-09-03T08:22:54.582Z 44 yes 46 Dilara Lale University of Veterinary Medicine Vienna 0000-0003-2360-8898 Antonia Geyer University of Veterinary Medicine Vienna person Christoph Jindra University of Veterinary Medicine Vienna person Jessika-Maximiliane V. Cavalleri University of Veterinary Medicine Vienna person 0000-0002-8575-7402 Anna Sophie Ramsauer University of Veterinary Medicine Vienna person 0000-0003-4741-3972 application/pdf 463042 https://phaidra.vetmeduni.ac.at/o:3473 no yes 18 70 1552253 Veterinary Record - Case Reports 6 11 1 Wiley 2022