Lale, Dilara (University of Veterinary Medicine Vienna) Geyer, Antonia (University of Veterinary Medicine Vienna) Jindra, Christoph (University of Veterinary Medicine Vienna) Cavalleri, Jessika-Maximiliane V. (University of Veterinary Medicine Vienna) Ramsauer, Anna Sophie (University of Veterinary Medicine Vienna) eng article Veterinary Record - Case Reports 11(1) (2022) A 28-year-old Icelandic horse gelding was presented with a laryngopharyngeal squamous cell carcinoma. The gelding had been treated for penile carcinoma in situ with a partial phallectomy 2 years earlier. Polymerase chain reaction of tumour DNA and subsequent amplicon sequencing revealed that the equine papillomavirus type 2 E6 oncogene sequences of both lesions were identical. There is strong evidence that equine papillomavirus type 2 is causally associated with genital squamous cell carcinomas and precancerous lesions. Recent reports indicate that equine papillomavirus type 2 might also play an active role in the pathogenesis of approximately 20% of equine squamous cell carcinomas in the oronasal, pharyngeal and laryngeal regions. To the authors' knowledge, this is the first report of a horse consecutively developing a penile carcinoma in situ and a laryngopharyngeal squamous cell carcinoma that were apparently induced by the same equine papillomavirus type 2 variant. Possible equine papillomavirus type 2 infection pathways in this horse and the importance of early detection of lesions are discussed in this context. Wiley application/pdf Equine papillomavirus type 2-associated, carcinomatous lesions of the penis and laryngopharynx of an elderly Icelandic horse gelding 2022 CC BY-NC-ND 4.0 International http://creativecommons.org/licenses/by-nc-nd/4.0/ doi:10.1002/vrc2.508 https://phaidra.vetmeduni.ac.at/o:3473 Squamous-Cell Carcinoma; Healthy Skin; Ecpv2; Dna; Prevalence; Amputation; Neoplasia; Proposal; Tumors