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<lom:catalog>DOI</lom:catalog>

  
<lom:entry>
  
<lom:langstring xml:lang="x-none">10.1002/vrc2.508</lom:langstring>

  
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<lom:title>
  
<lom:langstring xml:lang="en">Equine papillomavirus type 2-associated, carcinomatous lesions of the penis and laryngopharynx of an elderly Icelandic horse gelding</lom:langstring>

  
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<lom:description>
  
<lom:langstring xml:lang="en">A 28-year-old Icelandic horse gelding was presented with a laryngopharyngeal squamous cell carcinoma. The gelding had been treated for penile carcinoma in situ with a partial phallectomy 2 years earlier. Polymerase chain reaction of tumour DNA and subsequent amplicon sequencing revealed that the equine papillomavirus type 2 E6 oncogene sequences of both lesions were identical. There is strong evidence that equine papillomavirus type 2 is causally associated with genital squamous cell carcinomas and precancerous lesions. Recent reports indicate that equine papillomavirus type 2 might also play an active role in the pathogenesis of approximately 20% of equine squamous cell carcinomas in the oronasal, pharyngeal and laryngeal regions. To the authors&#39; knowledge, this is the first report of a horse consecutively developing a penile carcinoma in situ and a laryngopharyngeal squamous cell carcinoma that were apparently induced by the same equine papillomavirus type 2 variant. Possible equine papillomavirus type 2 infection pathways in this horse and the importance of early detection of lesions are discussed in this context.</lom:langstring>

  
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<lom:language>eng</lom:language>

  
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<lom:langstring xml:lang="en">Squamous-Cell Carcinoma; Healthy Skin; Ecpv2; Dna; Prevalence; Amputation; Neoplasia; Proposal; Tumors</lom:langstring>

  
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<lom:datetime>2024-09-03T08:26:32.103Z</lom:datetime>

  
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N:Lale;Dilara;
FN:Dilara Lale
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N:Geyer;Antonia;
FN:Antonia Geyer
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N:Jindra;Christoph;
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<lom:vcard>BEGIN:VCARD
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N:Cavalleri;Jessika-Maximiliane V.;
FN:Jessika-Maximiliane V. Cavalleri
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<lom:vcard>BEGIN:VCARD
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N:Ramsauer;Anna Sophie;
FN:Anna Sophie Ramsauer
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