Schistosoma sex-biased microRNAs regulate ovarian development and egg production by targeting Wnt signaling pathway

Pengfei Du; Tianqi Xia; Xuxin Li; Bikash R. Giri; Chuantao Fang; Shun Li; Shi Yan; Guofeng Cheng

doi:10.1038/s42003-024-07402-z

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Title (eng)

Schistosoma sex-biased microRNAs regulate ovarian development and egg production by targeting Wnt signaling pathway

Author

Pengfei Du

Tianqi Xia

Xuxin Li

Bikash R. Giri

Chuantao Fang

Shun Li

Shi Yan

University of Veterinary Medicine Vienna

Guofeng Cheng

Abstract (eng)

Adult Schistosoma produces a large number of eggs that play essential roles in host pathology and disease dissemination. Consequently, understanding the mechanisms of sexual maturation and egg production may open a new avenue for controlling schistosomiasis. Here, we describe that Bantam miRNA and miR-1989 regulate Wnt signaling pathway by targeting Frizzled-5/7/9, which is involved in ovarian development and oviposition. Additionally, Frizzled-7 could cooperate with SjRho to maintain normal ovarian development and egg productions and SjRho may interact with Hsp60 to potentially support Frizzled-7 trafficking and signaling. Further in vivo inhibition of SjRho in mice model infected with Schistosoma results in a remarkable decrease in worm burden and egg productions. Our findings not only broaden the functions of Bantam miRNA and miR-1989 as well as Wnt signaling pathway, but also imply that interruption of Bantam/miR-1989-Frizzled-5/7/9-SjRho axis may serve as effective targets against schistosomiasis.

Keywords (eng)

AnimalsFemaleFrizzled Receptors GeneticsFrizzled Receptors MetabolismMaleMiceMicroRNAs* GeneticsMicroRNAs* MetabolismOvary Growth & DevelopmentOvary MetabolismOvum Growth & DevelopmentOvum MetabolismSchistosoma GeneticsSchistosoma Growth & DevelopmentSchistosoma PphysiologySchistosoma Mansoni GeneticsSchistosoma Mansoni Growth & DevelopmentWnt Signaling Pathway

Type (eng)

journal article

Language

[eng]

Persistent identifier

https://phaidra.vetmeduni.ac.at/o:3851

DOI

10.1038/s42003-024-07402-z

Is in series

Title (eng)

Communications Biology

Volume