{"@context":{"aiiso":"http:\/\/purl.org\/vocab\/aiiso\/schema#","arm":"https:\/\/ld4p.github.io\/arm\/core\/ontology\/0.1\/","bf":"http:\/\/id.loc.gov\/ontologies\/bibframe\/","bib":"https:\/\/bibliotek-o.org\/","bibo":"http:\/\/purl.org\/ontology\/bibo\/","cito":"http:\/\/purl.org\/spar\/cito\/","classSchemes":"http:\/\/id.loc.gov\/vocabulary\/classSchemes","dbo":"http:\/\/dbpedia.org\/ontology\/","dce":"http:\/\/purl.org\/dc\/elements\/1.1\/","dcmitype":"http:\/\/dublincore.org\/documents\/2000\/07\/11\/dcmi-type-vocabulary\/#","dcterms":"http:\/\/purl.org\/dc\/terms\/","ebucore":"http:\/\/www.ebu.ch\/metadata\/ontologies\/ebucore\/ebucore","edm":"http:\/\/www.europeana.eu\/schemas\/edm\/","foaf":"http:\/\/xmlns.com\/foaf\/spec\/#","frap":"http:\/\/purl.org\/cerif\/frapo","identifiers":"http:\/\/id.loc.gov\/vocabulary\/identifiers","ids":"http:\/\/id.loc.gov\/vocabulary\/identifiers\/","opaque":"http:\/\/opaquenamespace.org\/","pcdm":"http:\/\/pcdm.org\/models#","phaidra":"https:\/\/phaidra.org\/ontology\/","rdam":"http:\/\/rdaregistry.info\/Elements\/m\/","rdau":"http:\/\/rdaregistry.info\/Elements\/u\/","rdax":"http:\/\/rdaregistry.info\/Elements\/x\/","rdf":"http:\/\/www.w3.org\/1999\/02\/22-rdf-syntax-ns#","rdfs":"https:\/\/www.w3.org\/TR\/rdf-schema\/","relators":"http:\/\/id.loc.gov\/vocabulary\/relators","role":{"@context":{"aut":{"@container":"@list","@id":"http:\/\/id.loc.gov\/vocabulary\/relators\/aut"}}},"schema":"http:\/\/schema.org\/","skos":"http:\/\/www.w3.org\/2004\/02\/skos\/core#","skosxl":"http:\/\/www.w3.org\/2008\/05\/skos-xl"},"@id":"https:\/\/phaidra.vetmeduni.ac.at\/o:3851","bf:note":[{"@type":"bf:Summary","skos:prefLabel":[{"@language":"eng","@value":"Adult Schistosoma produces a large number of eggs that play essential roles in host pathology and disease dissemination. Consequently, understanding the mechanisms of sexual maturation and egg production may open a new avenue for controlling schistosomiasis. Here, we describe that Bantam miRNA and miR-1989 regulate Wnt signaling pathway by targeting Frizzled-5\/7\/9, which is involved in ovarian development and oviposition. Additionally, Frizzled-7 could cooperate with SjRho to maintain normal ovarian development and egg productions and SjRho may interact with Hsp60 to potentially support Frizzled-7 trafficking and signaling. Further in vivo inhibition of SjRho in mice model infected with Schistosoma results in a remarkable decrease in worm burden and egg productions. Our findings not only broaden the functions of Bantam miRNA and miR-1989 as well as Wnt signaling pathway, but also imply that interruption of Bantam\/miR-1989-Frizzled-5\/7\/9-SjRho axis may serve as effective targets against schistosomiasis."}]}],"bf:provisionActivity":[{"@type":"bf:Publication","bf:agent":[{"@type":"schema:Organization","schema:name":[{"@value":"Springer Nature"}]}]}],"dce:rights":[{"@language":"eng","@value":"© The Author(s) 2024"}],"dce:subject":[{"@type":"skos:Concept","skos:prefLabel":[{"@language":"eng","@value":"Animals"}]},{"@type":"skos:Concept","skos:prefLabel":[{"@language":"eng","@value":"Female"}]},{"@type":"skos:Concept","skos:prefLabel":[{"@language":"eng","@value":"Frizzled Receptors Genetics"}]},{"@type":"skos:Concept","skos:prefLabel":[{"@language":"eng","@value":"Frizzled Receptors Metabolism"}]},{"@type":"skos:Concept","skos:prefLabel":[{"@language":"eng","@value":"Male"}]},{"@type":"skos:Concept","skos:prefLabel":[{"@language":"eng","@value":"Mice"}]},{"@type":"skos:Concept","skos:prefLabel":[{"@language":"eng","@value":"MicroRNAs* Genetics"}]},{"@type":"skos:Concept","skos:prefLabel":[{"@language":"eng","@value":"MicroRNAs* Metabolism"}]},{"@type":"skos:Concept","skos:prefLabel":[{"@language":"eng","@value":"Ovary Growth & Development"}]},{"@type":"skos:Concept","skos:prefLabel":[{"@language":"eng","@value":"Ovary Metabolism"}]},{"@type":"skos:Concept","skos:prefLabel":[{"@language":"eng","@value":"Ovum Growth & Development"}]},{"@type":"skos:Concept","skos:prefLabel":[{"@language":"eng","@value":"Ovum Metabolism"}]},{"@type":"skos:Concept","skos:prefLabel":[{"@language":"eng","@value":"Schistosoma Genetics"}]},{"@type":"skos:Concept","skos:prefLabel":[{"@language":"eng","@value":"Schistosoma Growth & Development"}]},{"@type":"skos:Concept","skos:prefLabel":[{"@language":"eng","@value":"Schistosoma Pphysiology"}]},{"@type":"skos:Concept","skos:prefLabel":[{"@language":"eng","@value":"Schistosoma Mansoni Genetics"}]},{"@type":"skos:Concept","skos:prefLabel":[{"@language":"eng","@value":"Schistosoma Mansoni Growth & Development"}]},{"@type":"skos:Concept","skos:prefLabel":[{"@language":"eng","@value":"Wnt Signaling Pathway"}]}],"dce:title":[{"@type":"bf:Title","bf:mainTitle":[{"@language":"eng","@value":"Schistosoma sex-biased microRNAs regulate ovarian development and egg production by targeting Wnt signaling pathway"}]}],"dcterms:accessRights":[{"@type":"skos:Concept","skos:exactMatch":["https:\/\/pid.phaidra.org\/vocabulary\/QW5R-NG4J"],"skos:prefLabel":[{"@language":"eng","@value":"open access"}]}],"dcterms:issued":["2024"],"dcterms:language":["eng"],"dcterms:type":[{"@type":"skos:Concept","skos:exactMatch":["https:\/\/pid.phaidra.org\/vocabulary\/69ZZ-2KGX"],"skos:prefLabel":[{"@language":"eng","@value":"Text"},{"@language":"deu","@value":"Text"}]}],"ebucore:filename":["C_107861.pdf"],"ebucore:hasMimeType":["application\/pdf"],"edm:hasType":[{"@type":"skos:Concept","skos:exactMatch":["https:\/\/pid.phaidra.org\/vocabulary\/VKA6-9XTY"],"skos:prefLabel":[{"@language":"eng","@value":"journal article"},{"@language":"deu","@value":"Wissenschaftlicher Artikel"}]}],"edm:rights":["http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"],"oaire:version":[{"@type":"skos:Concept","skos:exactMatch":["https:\/\/pid.phaidra.org\/vocabulary\/PMR8-3C8D"],"skos:prefLabel":[{"@language":"eng","@value":"version of record (published version)"}]}],"rdam:P30004":[{"@type":"ids:doi","@value":"10.1038\/s42003-024-07402-z"}],"rdau:P60193":[{"@type":"schema:CreativeWork","bibo:issue":["1"],"bibo:volume":["7"],"dce:title":[{"@type":"bf:Title","bf:mainTitle":[{"@language":"eng","@value":"Communications Biology"}]}],"dcterms:issued":["2024"],"ids:issn":["2399-3642"]}],"role:aut":[{"@type":"schema:Person","schema:familyName":[{"@value":"Du"}],"schema:givenName":[{"@value":"Pengfei"}]},{"@type":"schema:Person","schema:familyName":[{"@value":"Xia"}],"schema:givenName":[{"@value":"Tianqi"}]},{"@type":"schema:Person","schema:familyName":[{"@value":"Li"}],"schema:givenName":[{"@value":"Xuxin"}]},{"@type":"schema:Person","schema:familyName":[{"@value":"Giri"}],"schema:givenName":[{"@value":"Bikash R."}]},{"@type":"schema:Person","schema:familyName":[{"@value":"Fang"}],"schema:givenName":[{"@value":"Chuantao"}]},{"@type":"schema:Person","schema:familyName":[{"@value":"Li"}],"schema:givenName":[{"@value":"Shun"}]},{"@type":"schema:Person","schema:affiliation":[{"@type":"schema:Organization","schema:name":[{"@value":"University of Veterinary Medicine Vienna"}],"skos:exactMatch":["https:\/\/ror.org\/01w6qp003"]}],"schema:familyName":[{"@value":"Yan"}],"schema:givenName":[{"@value":"Shi"}],"skos:exactMatch":[{"@type":"ids:orcid","@value":"0000-0003-4949-9140"}]},{"@type":"schema:Person","schema:familyName":[{"@value":"Cheng"}],"schema:givenName":[{"@value":"Guofeng"}],"skos:exactMatch":[{"@type":"ids:orcid","@value":"0000-0001-5249-1065"}]}],"schema:numberOfPages":["14"]}