Titel (eng)

Malnutrition and Allergies: Tipping the Immune Balance towards Health

Autor*in

Emilia Vassilopoulou   International Hellenic University / University of Milan

Carina Venter   University of Colorado Anschutz Medical Campus

Franziska Roth-Walter   University of Veterinary Medicine Vienna / Medical University of Vienna

Verlag

MDPI

Beschreibung (eng)

Malnutrition, which includes macro- and micronutrient deficiencies, is common in individuals with allergic dermatitis, food allergies, rhinitis, and asthma. Prolonged deficiencies of proteins, minerals, and vitamins promote Th2 inflammation, setting the stage for allergic sensitization. Consequently, malnutrition, which includes micronutrient deficiencies, fosters the development of allergies, while an adequate supply of micronutrients promotes immune cells with regulatory and tolerogenic phenotypes. As protein and micronutrient deficiencies mimic an infection, the body's innate response limits access to these nutrients by reducing their dietary absorption. This review highlights our current understanding of the physiological functions of allergenic proteins, iron, and vitamin A, particularly regarding their reduced bioavailability under inflamed conditions, necessitating different dietary approaches to improve their absorption. Additionally, the role of most allergens as nutrient binders and their involvement in nutritional immunity will be briefly summarized. Their ability to bind nutrients and their close association with immune cells can trigger exaggerated immune responses and allergies in individuals with deficiencies. However, in nutrient-rich conditions, these allergens can also provide nutrients to immune cells and promote health.

Sprache des Objekts

Englisch

Datum

2024

Rechte

Creative Commons Lizenzvertrag
Dieses Werk bzw. dieser Inhalt steht unter einer
CC BY 4.0 - Creative Commons Namensnennung 4.0 International Lizenz.

CC BY 4.0 International

http://creativecommons.org/licenses/by/4.0/

Klassifikation

Iron-Deficiency Anemia; Lipid-Transfer Protein; Chronic Kidney-Disease; Vitamin-A-Deficiency; Cytokine Messenger-Rna; Innate Lymphoid-Cells; Bet V 1; Food Allergy; Retinoic Acid; Antioxidant Intake

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