phaidra.vetmeduni.ac.at o:3668 DOI 10.3390/jcm13164713 Malnutrition and Allergies: Tipping the Immune Balance towards Health Malnutrition, which includes macro- and micronutrient deficiencies, is common in individuals with allergic dermatitis, food allergies, rhinitis, and asthma. Prolonged deficiencies of proteins, minerals, and vitamins promote Th2 inflammation, setting the stage for allergic sensitization. Consequently, malnutrition, which includes micronutrient deficiencies, fosters the development of allergies, while an adequate supply of micronutrients promotes immune cells with regulatory and tolerogenic phenotypes. As protein and micronutrient deficiencies mimic an infection, the body's innate response limits access to these nutrients by reducing their dietary absorption. This review highlights our current understanding of the physiological functions of allergenic proteins, iron, and vitamin A, particularly regarding their reduced bioavailability under inflamed conditions, necessitating different dietary approaches to improve their absorption. Additionally, the role of most allergens as nutrient binders and their involvement in nutritional immunity will be briefly summarized. Their ability to bind nutrients and their close association with immune cells can trigger exaggerated immune responses and allergies in individuals with deficiencies. However, in nutrient-rich conditions, these allergens can also provide nutrients to immune cells and promote health. eng Iron-Deficiency Anemia; Lipid-Transfer Protein; Chronic Kidney-Disease; Vitamin-A-Deficiency; Cytokine Messenger-Rna; Innate Lymphoid-Cells; Bet V 1; Food Allergy; Retinoic Acid; Antioxidant Intake 2024-10-29T13:38:03.502Z LOMv1.0 Author BEGIN:VCARD VERSION:3.0 N:Vassilopoulou;Emilia; FN:Emilia Vassilopoulou X-ORCID:https://orcid.org/0000-0002-2665-5908 END:VCARD BEGIN:VCARD VERSION:3.0 N:Venter;Carina; FN:Carina Venter X-ORCID:https://orcid.org/0000-0002-7473-5355 END:VCARD BEGIN:VCARD VERSION:3.0 N:Roth-Walter;Franziska; FN:Franziska Roth-Walter X-ORCID:https://orcid.org/0000-0001-5005-9228 END:VCARD https://w3id.org/kim/hcrt/scheme https://w3id.org/kim/hcrt/text Textdokument Text LOMv1.0 yes https://creativecommons.org/licenses/by/4.0 application/pdf 1147077 https://phaidra.vetmeduni.ac.at/o:3668 https://phaidra.vetmeduni.ac.at/api/object/o:3668/thumbnail LOMv1.0 discipline