AP-1 transcription factors in cytotoxic lymphocyte development and antitumor immunity

Diana Schnoegl; Angela Hiesinger; Nicholas D. Huntington; Dagmar Gotthardt

doi:10.1016/j.coi.2023.102397

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Title

AP-1 transcription factors in cytotoxic lymphocyte development and antitumor immunity

Language

English

Description (en)

The proper functioning of cytotoxic lymphocytes, such as natural killer and CD8+ T cells, is essential for effective cancer-immunity and immunotherapy responses. The differentiation of these cells is controlled by several transcription factors (TFs), including members of the activator protein (AP)-1 family. The activity of AP-1 family members is regulated by various immune signaling pathways, which can be triggered by activating or inhibitory receptors as well as cytokines. The target genes controlled by AP-1 TFs are central to generate immunity to pathogens or malignancies. Here, we provide an overview of the current understanding of how AP-1 TFs regulate cytotoxic lymphocytes.

Keywords (en)

T-Cells; Nk-Cells; Gene; Activation; Exhaustion; Expression; Batf; Differentiation; Identification; Proteins

DOI

10.1016/j.coi.2023.102397

Author of the digital object

Diana Schnoegl (Medical University of Graz / Monash University)

Dagmar Gotthardt (University of Veterinary Medicine Vienna)

Angela Hiesinger (University of Veterinary Medicine Vienna)

Nicholas D. Huntington (Monash University)

Format

application/pdf

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