Footprints of Worldwide Adaptation in Structured Populations of "Drosophila melanogaster" Through the Expanded DEST 2.0 Genomic Resource
Title (eng)
Footprints of Worldwide Adaptation in Structured Populations of "Drosophila melanogaster" Through the Expanded DEST 2.0 Genomic Resource
Author
Antonio J Buendia-Ruíz
Bélen Roldán Matrín
Christian Feller
Christian Schlötterer
Genetics and Animal Breeding, Centre of Biological Sciences, Department of Biological Sciences and Pathobiology, University of Veterinary Medicine Vienna, Vienna, Austria
Joan Torro
Jose Luis Olmo
Krzysztof Wojciechowski
M Josefa Gómez-Julián
M Luisa Espinosa-Jimenez
Paloma Sepulveda
Jorge Roberto Torres
Silvana Castillo
Zahara Alonso
Abstract (eng)
Large-scale genomic resources can place genetic variation into an ecologically informed context. To advance our understanding of the population genetics of the fruit fly Drosophila melanogaster, we present an expanded release of the community-generated population genomics resource Drosophila Evolution over Space and Time (DEST 2.0; dest.bio). This release includes 530 high-quality pooled libraries from flies collected across six continents over more than a decade (2009 to 2021), most at multiple time points per year; 211 of these libraries are sequenced and shared here for the first time. We used this enhanced resource to elucidate several aspects of the species' demographic history and identify novel signs of adaptation across spatial and temporal dimensions. For example, we showed that the spatial genetic structure of populations is stable over time, but that drift due to seasonal contractions of population size causes populations to diverge over time. We identified signals of adaptation that vary between continents in genomic regions associated with xenobiotic resistance, consistent with independent adaptation to common pesticides. Moreover, by analyzing samples collected during spring and fall across Europe, we provide new evidence for seasonal adaptation related to loci associated with pathogen response. Furthermore, we have also released an updated version of the DEST genome browser. This is a useful tool for studying spatiotemporal patterns of genetic variation in this classic model system.
Keywords (eng)
Drosophila MelanogasterDatasetPopulation StructureSeasonal SelectionLocal AdaptionEcological Genomics
Type (eng)
Language
[eng]
Persistent identifier
Is in series
Title (eng)
Molecular Biology and Evolution
Volume
42
Issue
8
ISSN
0737-4038
Issued
2025
Number of pages
28
Publication
Oxford University Press
Version type (eng)
Date issued
2025
Access rights (eng)
License
Rights statement (eng)
© The Author(s) 2025
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https://phaidra.vetmeduni.ac.at/o:5054 - Other links and identifiers
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- RightsLicenseRights statement© The Author(s) 2025
- DetailsResource typeText (PDF)Formatapplication/pdfCreated20.04.2026 09:28:19 UTC
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