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Title (en)
Immunohistochemical markers for equine granulosa cell tumors: a pilot study
Language
English
Description (en)
Sex cord-stromal tumors (SCSTs), generally referred to as granulosa cell tumors (GCTs) or granulosa-theca cell tumors (GTCTs) in equids, show complex compositions and variable numbers of hormone-producing cells. These tumors can be difficult to diagnose, especially in early stages. Therefore, we tested a panel of antibodies for vimentin, smooth muscle actin, laminin, Ki-67, E-cadherin, calretinin, moesin, p-ezrin, AMH, and aromatase, markers used for tumor composition and classification, progression, and prognosis in human SCSTs, on an exemplary grapefruit-size equine GCT within the left ovary of a 13-year-old mare with stallion-like behavior and elevated testosterone levels in comparison with normal ovarian tissue. The tumor showed a low proliferation rate and prominent moesin and p-ezrin staining in granulosa cells. E-cadherin, calretinin, aromatase, and AMH are suggested to be potential markers for different cell components of equine SCSTs that can support tumor diagnosis and classification.
Keywords (en)
Diagnostic Marker, Horse; Ovary; Tumor
DOI
10.1294/jes.34.37
Author of the digital object
Aurelia Dolin  (Veterinary Practice Tierdoc)
Peter Schweiger  (Veterinary Practice Tierdoc)
Martin Waselau  (Equine Hospital Aschheim)
Monika Egerbacher  (UMIT - Private Universität für Gesundheitswissenschaften, Medizinische Informatik und Technik)
Ingrid Walter  (University of Veterinary Medicine Vienna)
Licence Selected
CC BY-NC-ND 4.0 International
Type of publication
Article
Name of Publication (en)
Journal of Equine Science
Pages or Volume
10
Volume
34
Number
2
From Page
37
To Page
46
Publisher
J-Stage
Publication Date
2023