phaidra.vetmeduni.ac.at o:3589 DOI 10.1294/jes.34.37 Immunohistochemical markers for equine granulosa cell tumors: a pilot study Sex cord-stromal tumors (SCSTs), generally referred to as granulosa cell tumors (GCTs) or granulosa-theca cell tumors (GTCTs) in equids, show complex compositions and variable numbers of hormone-producing cells. These tumors can be difficult to diagnose, especially in early stages. Therefore, we tested a panel of antibodies for vimentin, smooth muscle actin, laminin, Ki-67, E-cadherin, calretinin, moesin, p-ezrin, AMH, and aromatase, markers used for tumor composition and classification, progression, and prognosis in human SCSTs, on an exemplary grapefruit-size equine GCT within the left ovary of a 13-year-old mare with stallion-like behavior and elevated testosterone levels in comparison with normal ovarian tissue. The tumor showed a low proliferation rate and prominent moesin and p-ezrin staining in granulosa cells. E-cadherin, calretinin, aromatase, and AMH are suggested to be potential markers for different cell components of equine SCSTs that can support tumor diagnosis and classification. eng Diagnostic Marker, Horse; Ovary; Tumor 2024-10-14T08:41:20.599Z LOMv1.0 Author BEGIN:VCARD VERSION:3.0 N:Dolin;Aurelia; FN:Aurelia Dolin END:VCARD BEGIN:VCARD VERSION:3.0 N:Schweiger;Peter; FN:Peter Schweiger END:VCARD BEGIN:VCARD VERSION:3.0 N:Waselau;Martin; FN:Martin Waselau END:VCARD BEGIN:VCARD VERSION:3.0 N:Egerbacher;Monika; FN:Monika Egerbacher END:VCARD BEGIN:VCARD VERSION:3.0 N:Walter;Ingrid; FN:Ingrid Walter X-ORCID:https://orcid.org/0000-0002-5038-188X END:VCARD https://w3id.org/kim/hcrt/scheme https://w3id.org/kim/hcrt/text Textdokument Text LOMv1.0 yes https://creativecommons.org/licenses/by-nc-nd/4.0 application/pdf 4509655 https://phaidra.vetmeduni.ac.at/o:3589 https://phaidra.vetmeduni.ac.at/api/object/o:3589/thumbnail LOMv1.0 discipline