Dolin, Aurelia (Veterinary Practice Tierdoc) Aurelia Dolin Schweiger, Peter (Veterinary Practice Tierdoc) Peter Schweiger Waselau, Martin (Equine Hospital Aschheim) Martin Waselau Egerbacher, Monika (UMIT - Private Universität für Gesundheitswissenschaften, Medizinische Informatik und Technik) Monika Egerbacher Walter, Ingrid (University of Veterinary Medicine Vienna) Ingrid Walter J-Stage 2023 Sex cord-stromal tumors (SCSTs), generally referred to as granulosa cell tumors (GCTs) or granulosa-theca cell tumors (GTCTs) in equids, show complex compositions and variable numbers of hormone-producing cells. These tumors can be difficult to diagnose, especially in early stages. Therefore, we tested a panel of antibodies for vimentin, smooth muscle actin, laminin, Ki-67, E-cadherin, calretinin, moesin, p-ezrin, AMH, and aromatase, markers used for tumor composition and classification, progression, and prognosis in human SCSTs, on an exemplary grapefruit-size equine GCT within the left ovary of a 13-year-old mare with stallion-like behavior and elevated testosterone levels in comparison with normal ovarian tissue. The tumor showed a low proliferation rate and prominent moesin and p-ezrin staining in granulosa cells. E-cadherin, calretinin, aromatase, and AMH are suggested to be potential markers for different cell components of equine SCSTs that can support tumor diagnosis and classification. PDFDocument en 2024-10-14T08:36:22.688Z Diagnostic Marker, Horse; Ovary; Tumor 4509655 b application/pdf CC BY-NC-ND 4.0 International