Functionalization of 68Ga-Radiolabeled Nanodiamonds with Octreotide Does Not Improve Tumor-Targeting Capabilities

Thomas Wanek; Marco Raabe; Md Noor A Alam; Thomas Filip; Johann Stanek; Mathilde Loebsch; Christian Laube; Severin Mairinger; Tanja Weil; Claudia Kuntner

doi:10.3390/ph17040514

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Title (eng)

Functionalization of 68Ga-Radiolabeled Nanodiamonds with Octreotide Does Not Improve Tumor-Targeting Capabilities

Author

Thomas Wanek

Marco Raabe

Md Noor A Alam

Thomas Filip

University of Veterinary Medicine Vienna

Johann Stanek

Mathilde Loebsch

Christian Laube

Severin Mairinger

Tanja Weil

Claudia Kuntner

Abstract (eng)

Nanodiamonds (NDs) are emerging as a novel nanoparticle class with growing interest in medical applications. The surface coating of NDs can be modified by attaching binding ligands or imaging probes, turning them into multi-modal targeting agents. In this investigation, we assessed the targeting efficacy of octreotide-functionalized 68Ga-radiolabelled NDs for cancer imaging and compared it with the tumor uptake using [68Ga]Ga-DOTA-TOC. In vivo studies in mice bearing AR42J tumors demonstrated the highest accumulation of the radiolabeled functionalized NDs in the liver and spleen, with relatively low tumor uptake compared to [68Ga]Ga-DOTA-TOC. Our findings suggest that, within the scope of this study, functionalization did not enhance the tumor-targeting capabilities of NDs.

Keywords (eng)

NanodiamondsSmall Animal PETPreclinical ImagingAR42J Tumor-Bearing Mice

Type (eng)

journal article

Language

[eng]

Persistent identifier

https://phaidra.vetmeduni.ac.at/o:4400

DOI

10.3390/ph17040514

Is in series

Title (eng)