Nutrition in chronic inflammatory conditions: Bypassing the mucosal block for micronutrients

Franziska Roth-Walter; Roberto Berni Canani; Liam O'Mahony,; Diego Peroni; Milena Sokolowska; Emilia Vassilopoulou; Carina Venter

doi:10.1111/all.15972

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Title (eng)

Nutrition in chronic inflammatory conditions: Bypassing the mucosal block for micronutrients

Author

Franziska Roth-Walter

University of Veterinary Medicine Vienna

Roberto Berni Canani

Liam O'Mahony,

Diego Peroni

Milena Sokolowska

Emilia Vassilopoulou

Carina Venter

Abstract (eng)

Nutritional Immunity is one of the most ancient innate immune responses, during which the body can restrict nutrients availability to pathogens and restricts their uptake by the gut mucosa (mucosal block). Though this can be a beneficial strategy during infection, it also is associated with non-communicable diseases-where the pathogen is missing; leading to increased morbidity and mortality as micronutritional uptake and distribution in the body is hindered. Here, we discuss the acute immune response in respect to nutrients, the opposing nutritional demands of regulatory and inflammatory cells and particularly focus on some nutrients linked with inflammation such as iron, vitamins A, Bs, C, and other antioxidants. We propose that while the absorption of certain micronutrients is hindered during inflammation, the dietary lymph path remains available. As such, several clinical trials investigated the role of the lymphatic system during protein absorption, following a ketogenic diet and an increased intake of antioxidants, vitamins, and minerals, in reducing inflammation and ameliorating disease.

Remark

Correction(s) for this article: Corrigendum to “Nutrition in chronic inflammatory conditions: Bypassing the mucosal block for micronutrients” doi.org/10.1111/all.16177

Keywords (eng)

HumansMicronutrients Therapeutic UseVitamins Therapeutic UseAntioxidants MetabolismVitamin AInflammation Drug TherapyMucous Membrane Metabolism

Type (eng)

journal article

Language

[eng]

Persistent identifier

https://phaidra.vetmeduni.ac.at/o:4232

DOI

10.1111/all.15972

Is in series

Title (eng)