Titel (eng)

Long-Term Preclinical Evaluation of a Permanent Stent Developed for the Human Eustachian Tube

Autor*in

Katharina Schmitt   Medizinische Hochschule Hannover

Gerrit Paasche   Medizinische Hochschule Hannover

Tobias Stein   bess pro GmbH

Thomas Lenarz   Medizinische Hochschule Hannover

Marion Bankstahl   Medizinische Hochschule Hannover / University of Veterinary Medicine Vienna

Lisa Kötter   Medizinische Hochschule Hannover

Andreas Kampmann   Medizinische Hochschule Hannover

Robert Schuon   Medizinische Hochschule Hannover

Friederike Pohl   Medizinische Hochschule Hannover

Alexandra Napp   Medizinische Hochschule Hannover

Niels Oppel   Medizinische Hochschule Hannover

Malena Timm   Medizinische Hochschule Hannover

Philipp Krüger   bess pro GmbH

Verlag

MDPI

Beschreibung (eng)

The Eustachian tube (ET) is a bottleneck when it comes to middle ear (ME) health. If its function is impaired, this can lead to serious consequences for the patient, such as hearing problems or deafness. Therefore, this study investigated a tapered nitinol stent (3-5 mm × 14 mm) for the human ET as a potential new permanent treatment for chronic Eustachian tube dysfunction (ETD) and thus ME ventilation disorders. The self-expanding stent was inserted unilaterally into the ET of 24 sheep with observation periods of 3, 6, and 12 months. Local tissue effects and the safety of the stent insertion were analyzed based on regular endoscopic checks, weekly tympanometry measurements, final imaging, and histological examinations. The animals showed no stent-related health restrictions. However, the individual anatomy and stenting procedure had an influence on the results. The tissue reaction in the endoscopic examinations was mild even though no concomitant antibiotics were administered. After all three monitoring periods, stented ETs had a significantly larger ET lumen than the non-stented contralateral ETs. However, tissue growth was detected in the stent. Overall, the first long-term study on an ET stent showed that the tapered ET stent could be a promising treatment option for ETD.

Sprache des Objekts

Englisch

Datum

2024

Rechte

Dieses Werk bzw. dieser Inhalt steht unter einer
CC BY 4.0 - Creative Commons Namensnennung 4.0 International Lizenz.

CC BY 4.0 International

http://creativecommons.org/licenses/by/4.0/

Klassifikation

Nitinol Stent; Eustachian Tube; Tympanometry; Histology; CBCT; ETD Treatment; Self-expanding Metallic Stent; In Vivo; Sheep

Mitglied in der/den Collection(s) (1)