Titel (eng)

No negative effects of intra-abdominal bio-logger implantation under general anaesthesia on spatial cognition learning in a hibernator the edible dormouse

Autor*in

Tabea Loreen Lammert   University of Veterinary Medicine Vienna

Friederike Pohlin   University of Veterinary Medicine Vienna

Claudia Bieber   University of Veterinary Medicine Vienna

Thomas Ruf   University of Veterinary Medicine Vienna

Johanna Painer-Gigler   University of Veterinary Medicine Vienna

Gabrielle Stalder   University of Veterinary Medicine Vienna

Jessica Svea Cornils   University of Veterinary Medicine Vienna

Ursula Teubenbacher   University of Veterinary Medicine Vienna

Jan Müller   University of Veterinary Medicine Vienna

Susana Carolina Ferreira   University of Veterinary Medicine Vienna

Verlag

Public Library of Science

Beschreibung (eng)

The effect of hibernation on cognitive capacities of individuals is not fully understood, as studies provide conflicting results. Most studies focus on behavioural observations without taking the physiological state of individuals to account. To mechanistically understand the effect of hibernation on the brain, physiological parameters need to be included. The implantation of bio-loggers can provide insights on i.e. body temperature without further manipulation of the animals. Surgeries and anaesthesia, however, can harm animals' health and cause cognitive dysfunction, potentially biasing data collected through bio-loggers. We investigated the effects of bio-logger implantation surgery on cognitive performance and learning, controlling for animal and study design characteristics. First, juvenile dormice successfully learned to solve a spatial cognition task using a vertical maze. Distance, transitions, velocity, and duration were measured as indicators for performance. After training, bio-loggers were implanted intra-abdominally under general anaesthesia. Animals were re-tested in the maze two weeks after. We found no effect of bio-logger implantation and surgery on performance. This study is the first to show spatial cognition learning in edible dormice and provides a full description of the peri-anaesthetic management and a protocol for bio-logger implantation surgery in dormice. Importantly, measures were taken to mitigate common anaesthetic complications that could lead to post-operative cognitive dysfunction and influence animal behaviour. By pairing physiological measurements through bio-logger implantation with behaviour and cognition measurements, future research will significantly advance the understanding on mechanisms of learning and behaviour.

Sprache des Objekts

Englisch

Datum

2024

Rechte

Creative Commons Lizenzvertrag
Dieses Werk bzw. dieser Inhalt steht unter einer
CC BY 4.0 - Creative Commons Namensnennung 4.0 International Lizenz.

CC BY 4.0 International

http://creativecommons.org/licenses/by/4.0/

Klassifikation

Animals; Cognition; Anesthesia, General; Hibernation; Maze Learning; Spatial Learning; Male

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