Title
Hematopoietic cell-derived IL-15 supports NK cell development in scattered and clustered localization within the bone marrow
Language
English
Description (en)
Natural killer (NK) cells are innate immune cells critical for protective immune responses against infection and cancer. Although NK cells differentiate in the bone marrow (BM) in an interleukin-15 (IL-15)-dependent manner, the cellular source of IL-15 remains elusive. Using NK cell reporter mice, we show that NK cells are localized in the BM in scattered and clustered manners. NK cell clusters overlap with monocyte and dendritic cell accumulations, whereas scattered NK cells require CXCR4 signaling. Using cell-specific IL-15-deficient mice, we show that hematopoietic cells, but not stromal cells, support NK cell development in the BM through IL-15. In particular, IL-15 produced by monocytes and dendritic cells appears to contribute to NK cell development. These results demonstrate that hematopoietic cells are the IL-15 niche for NK cell development in the BM and that BM NK cells are present in scattered and clustered compartments by different mechanisms, suggesting their distinct functions in the immune response.
Keywords (en)
Mice; Animals; Bone Marrow; Interleukin-15; Bone Marrow Cells; Cell Differentiation; Killer Cells, Natural
DOI
10.1016/j.celrep.2023.113127
Author of the digital object
Shinya  Abe  (Kyoto University)
Koichi  Ikuta  (Kyoto University)
Takashi  Nagasawa  (Osaka University)
Veronika  Sexl  (University of Veterinary Medicine Vienna)
Masaru  Ishii  (Osaka University)
Toshiaki  Ohteki  (Tokyo Medical and Dental University)
Ryo  Yamada  (Kyoto University)
Masaki  Miyazaki  (Kyoto University)
Alexis  Vandenbon  (Kyoto University)
Junichi  Kikuta  (Osaka University)
Naotoshi  Nakamura  (Nagoya University)
Satsuki  Kitano  (Kyoto University)
Hitoshi  Miyachi  (Kyoto University)
Kazuko  Miyazaki  (Kyoto University)
Kohei  Yamada  (Kyoto University)
Shizue  Tani-Ichi  (Kyoto University)
Akihiro  Shimba  (Kyoto University)
Guangwei  Cui  (Kyoto University)
Takuma  Asahi  (Kyoto University)
Takahiro  Hara  (Kyoto University)
Format
application/pdf
Size
8.7 MB
Licence Selected
CC BY 4.0 International
Type of publication
Article
Name of Publication (en)
Cell Reports
Pages or Volume
24
Volume
42
Number
9
Publisher
Cell Press
Publication Date
2023
Content
Details
Object type
PDFDocument
Format
application/pdf
Created
09.02.2024 09:04:15
This object is in collection
Metadata
Veterinärmedizinische Universität Wien (Vetmeduni) | Veterinärplatz 1 | 1210 Wien - Österreich | T +43 1 25077-0 | Web: vetmeduni.ac.at