Titel (eng)

Hematopoietic cell-derived IL-15 supports NK cell development in scattered and clustered localization within the bone marrow

Autor*in

Shinya Abe   Kyoto University

Koichi Ikuta   Kyoto University

Takashi Nagasawa   Osaka University

Veronika Sexl   University of Veterinary Medicine Vienna

Masaru Ishii   Osaka University

Toshiaki Ohteki   Tokyo Medical and Dental University

Ryo Yamada   Kyoto University

Masaki Miyazaki   Kyoto University

Alexis Vandenbon   Kyoto University

Junichi Kikuta   Osaka University

Naotoshi Nakamura   Nagoya University

Satsuki Kitano   Kyoto University

Hitoshi Miyachi   Kyoto University

Kazuko Miyazaki   Kyoto University

Kohei Yamada   Kyoto University

Shizue Tani-Ichi   Kyoto University

Akihiro Shimba   Kyoto University

Guangwei Cui   Kyoto University

Takuma Asahi   Kyoto University

Takahiro Hara   Kyoto University

Verlag

Cell Press

Beschreibung (eng)

Natural killer (NK) cells are innate immune cells critical for protective immune responses against infection and cancer. Although NK cells differentiate in the bone marrow (BM) in an interleukin-15 (IL-15)-dependent manner, the cellular source of IL-15 remains elusive. Using NK cell reporter mice, we show that NK cells are localized in the BM in scattered and clustered manners. NK cell clusters overlap with monocyte and dendritic cell accumulations, whereas scattered NK cells require CXCR4 signaling. Using cell-specific IL-15-deficient mice, we show that hematopoietic cells, but not stromal cells, support NK cell development in the BM through IL-15. In particular, IL-15 produced by monocytes and dendritic cells appears to contribute to NK cell development. These results demonstrate that hematopoietic cells are the IL-15 niche for NK cell development in the BM and that BM NK cells are present in scattered and clustered compartments by different mechanisms, suggesting their distinct functions in the immune response.

Sprache des Objekts

Englisch

Datum

2023

Rechte

Dieses Werk bzw. dieser Inhalt steht unter einer
CC BY 4.0 - Creative Commons Namensnennung 4.0 International Lizenz.

CC BY 4.0 International

http://creativecommons.org/licenses/by/4.0/

Klassifikation

Mice; Animals; Bone Marrow; Interleukin-15; Bone Marrow Cells; Cell Differentiation; Killer Cells, Natural

Mitglied in der/den Collection(s) (1)