Titel (eng)

Formerly bile-farmed bears as a model of accelerated ageing

Autor*in

Szilvia K. Kalogeropoulu   University of Veterinary Medicine Vienna

Johanna Painer-Gigler   University of Veterinary Medicine Vienna

Iwan A. Burgener   University of Veterinary Medicine Vienna

Irene Redtenbacher   Four Paws International

Ole Fröbert   Örebro University / Aarhus University Hospital / Aarhus University

Richard J. Johnson   University of Colorado Anschutz Medical Campus

Paul G. Shiels   University of Glasgow

Peter Stenvinkel   Karolinska Institutet

Hanna Rauch-Schmücking   University of Veterinary Medicine Vienna

Emily J. Lloyd   Four Paws Vietnam

Verlag

Nature Portfolio

Beschreibung (eng)

Bear bile-farming is common in East and Southeast Asia and this farming practice often results in irreversible health outcomes for the animals. We studied long-term effects of chronic bacterial and sterile hepatobiliary inflammation in 42 Asiatic black bears (Ursus thibetanus) rescued from Vietnamese bile farms. The bears were examined under anesthesia at least twice as part of essential medical interventions. All bears were diagnosed with chronic low-grade sterile or bacterial hepatobiliary inflammation along with pathologies from other systems. Our main finding was that the chronic low-grade inflammatory environment associated with bile extraction in conjunction with the suboptimal living conditions on the farms promoted and accelerated the development of age-related pathologies such as chronic kidney disease, obese sarcopenia, cardiovascular remodeling, and degenerative joint disease. Through a biomimetic approach, we identified similarities with inflammation related to premature aging in humans and found significant deviations from the healthy ursid phenotype. The pathological parallels with inflammageing and immuno-senescence induced conditions in humans suggest that bile-farmed bears may serve as animal models to investigate pathophysiology and deleterious effects of lifestyle-related diseases.

Sprache des Objekts

Englisch

Datum

2023

Rechte

Creative Commons Lizenzvertrag
Dieses Werk bzw. dieser Inhalt steht unter einer
CC BY 4.0 - Creative Commons Namensnennung 4.0 International Lizenz.

CC BY 4.0 International

http://creativecommons.org/licenses/by/4.0/

Klassifikation

Chronic Kidney-Disease; Stage Renal-Disease; Chronic Inflammation; Mechanism; Guidelines; Sarcopenia; Insights; Stress

Mitglied in der/den Collection(s) (1)

o:605 Publikationen / Veterinärmedizinische Universität Wien