Herbicide glyphosate efficiently inhibits growth of pathogenic Prototheca algae species, suggesting the presence of novel pathways for the development of anti-algal drugs

Olga Makarova; Diana Steinke; Uwe Roesler

doi:10.1128/spectrum.02343-24

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Title (eng)

Herbicide glyphosate efficiently inhibits growth of pathogenic Prototheca algae species, suggesting the presence of novel pathways for the development of anti-algal drugs

Author

Olga Makarova

University of Veterinary Medicine Vienna

Diana Steinke

Uwe Roesler

Abstract (eng)

Prototheca are ubiquitous algae and occasional pathogens of humans and animals. While rare, the infection is often fatal and treatment options are limited to antifungals with low efficiency. Here, using growth curve assays, we demonstrate that five pathogenic species of Prototheca (P. blaschkeae, P. wickerhamii, P. cutis, P. ciferrii, P. bovis) were fully inhibited by 50–100 μg/mL of herbicide glyphosate, suggesting novel pathways that can be considered for anti-algal drug development.

Keywords (eng)

GlyphosateGlycine Analogs & DerivativesGlycine PharmacologyHerbicides PharmacologyPrototheca Drug EffectsProtothecadrug Growth & DevelopmentPrototheca GeneticsHumansAnimalsAntifungal Agents Pharmacology

Type (eng)

journal article

Language

[eng]

Persistent identifier

https://phaidra.vetmeduni.ac.at/o:3993

DOI

10.1128/spectrum.02343-24

Is in series

Title (eng)

Microbiology Spectrum

Volume