Titel (eng)

Differential regulation of mitochondrial uncoupling protein 2 in cancer cells

Autor*in

Taraneh Beikbaghban   University of Veterinary Medicine Vienna

Elena E. Pohl   University of Veterinary Medicine Vienna

Felix Sternberg   University of Veterinary Medicine Vienna

Florian Grebien   University of Veterinary Medicine Vienna / St. Anna Children's Cancer Research Institute / CeMM Research Center for Molecular Medicine

Thomas Weichhart   Medical University of Vienna

Thomas Rattei   University of Vienna

Roko Sango   University of Vienna / Medical University of Vienna

Ludovica Proietti   University of Veterinary Medicine Vienna

Jessica Ebner   University of Veterinary Medicine Vienna

Verlag

Elsevier

Beschreibung (eng)

The persistent growth of cancer cells is underscored by complex metabolic reprogramming, with mitochondria playing a key role in the transition to aerobic glycolysis and representing new therapeutic targets. Mitochondrial uncoupling protein 2 (UCP2) has attracted interest because of its abundance in rapidly proliferating cells, including cancer cells, and its involvement in cellular metabolism. However, the specific contributions of UCP2 to cancer biology remain poorly defined. Our investigation of UCP2 expression in various human and mouse cancer cell lines aimed to elucidate its links to metabolic states, proliferation, and adaptation to environmental stresses such as hypoxia and nutrient deprivation. We observed significant variability in UCP2 expression across cancer types, with no direct correlation to their metabolic activity or proliferation rates. UCP2 abundance was also differentially affected by nutrient availability in different cancer cells, but UCP2 was generally downregulated under hypoxia. These findings challenge the notion that UCP2 is a marker of malignant potential and suggest its more complex involvement in the metabolic landscape of cancer.

Sprache des Objekts

Englisch

Datum

2024

Rechte

Dieses Werk bzw. dieser Inhalt steht unter einer
CC BY 4.0 - Creative Commons Namensnennung 4.0 International Lizenz.

CC BY 4.0 International

http://creativecommons.org/licenses/by/4.0/

Klassifikation

Warburg Effect; Oxygen Consumption Rate; Extracellular Acidification Rate; Uncouplers; Metabolite Transport; Citric Acid Cycle; Pyruvate Kinase

Mitglied in der/den Collection(s) (1)