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<lom:identifier>
  
<lom:catalog>DOI</lom:catalog>

  
<lom:entry>
  
<lom:langstring xml:lang="x-none">10.1016/j.bbabio.2024.149486</lom:langstring>

  
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</lom:identifier>

  
<lom:title>
  
<lom:langstring xml:lang="en">Differential regulation of mitochondrial uncoupling protein 2 in cancer cells</lom:langstring>

  
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<lom:description>
  
<lom:langstring xml:lang="en">The persistent growth of cancer cells is underscored by complex metabolic reprogramming, with mitochondria playing a key role in the transition to aerobic glycolysis and representing new therapeutic targets. Mitochondrial uncoupling protein 2 (UCP2) has attracted interest because of its abundance in rapidly proliferating cells, including cancer cells, and its involvement in cellular metabolism. However, the specific contributions of UCP2 to cancer biology remain poorly defined. Our investigation of UCP2 expression in various human and mouse cancer cell lines aimed to elucidate its links to metabolic states, proliferation, and adaptation to environmental stresses such as hypoxia and nutrient deprivation. We observed significant variability in UCP2 expression across cancer types, with no direct correlation to their metabolic activity or proliferation rates. UCP2 abundance was also differentially affected by nutrient availability in different cancer cells, but UCP2 was generally downregulated under hypoxia. These findings challenge the notion that UCP2 is a marker of malignant potential and suggest its more complex involvement in the metabolic landscape of cancer.</lom:langstring>

  
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<lom:language>eng</lom:language>

  
<lom:keyword>
  
<lom:langstring xml:lang="en">Warburg Effect; Oxygen Consumption Rate; Extracellular Acidification Rate; Uncouplers; Metabolite Transport; Citric Acid Cycle; Pyruvate Kinase</lom:langstring>

  
</lom:keyword>

  
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<lom:datetime>2024-10-25T08:49:01.261Z</lom:datetime>

  
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<lom:vcard>BEGIN:VCARD
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N:Beikbaghban;Taraneh;
FN:Taraneh Beikbaghban
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<lom:vcard>BEGIN:VCARD
VERSION:3.0
N:Pohl;Elena E.;
FN:Elena E. Pohl
X-ORCID:https://orcid.org/0000-0002-0604-5950
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<lom:vcard>BEGIN:VCARD
VERSION:3.0
N:Sternberg;Felix;
FN:Felix Sternberg
END:VCARD</lom:vcard>

  
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<lom:vcard>BEGIN:VCARD
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N:Grebien;Florian;
FN:Florian Grebien
X-ORCID:https://orcid.org/0000-0003-4289-2281
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<lom:vcard>BEGIN:VCARD
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N:Weichhart;Thomas;
FN:Thomas Weichhart
END:VCARD</lom:vcard>

  
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<lom:vcard>BEGIN:VCARD
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N:Rattei;Thomas;
FN:Thomas Rattei
END:VCARD</lom:vcard>

  
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N:Sango;Roko;
FN:Roko Sango
END:VCARD</lom:vcard>

  
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N:Proietti;Ludovica;
FN:Ludovica Proietti
X-ORCID:https://orcid.org/0000-0002-3077-0079
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<lom:vcard>BEGIN:VCARD
VERSION:3.0
N:Ebner;Jessica;
FN:Jessica Ebner
X-ORCID:https://orcid.org/0000-0002-4606-6051
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