Title (eng)

Characterization of a Syngeneic Orthotopic Model of Cholangiocarcinoma by [18F]FDG-PET/MRI

Author

Lena Zachhuber   University of Vienna / Medical University of Vienna

Claudia Kuntner   Medical University of Vienna

Walter Berger   Medical University of Vienna

Thomas Wanek   Medical University of Vienna

Thomas H. Helbich   Medical University of Vienna

Marcus Hacker   Medical University of Vienna

Johann Stanek   Medical University of Vienna

Petra Vician   Medical University of Vienna

Stefan Scheiner   Medical University of Vienna

Mathilde Löbsch   Medical University of Vienna

Thomas Filip   University of Veterinary Medicine Vienna

Behrang Mozayani   Medical University of Vienna

Publishing

MDPI

Description (eng)

Cholangiocarcinoma (CCA) is a type of primary liver cancer originating from the biliary tract epithelium, characterized by limited treatment options for advanced cases and low survival rates. This study aimed to establish an orthotopic mouse model for CCA and monitor tumor growth using PET/MR imaging. Murine CCA cells were implanted into the liver lobe of male C57BL/6J mice. The imaging groups included contrast-enhanced (CE) MR, CE-MR with static [18F]FDG-PET, and dynamic [18F]FDG-PET. Tumor volume and FDG uptake were measured weekly over four weeks. Early tumor formation was visible in CE-MR images, with a gradual increase in volume over time. Dynamic FDG-PET revealed an increase in the metabolic glucose rate (MRGlu) over time. Blood analysis showed pathological changes in liver-related parameters. Lung metastases were observed in nearly all animals after four weeks. The study concludes that PET-MR imaging effectively monitors tumor progression in the CCA mouse model, providing insights into CCA development and potential treatment strategies.

Object languages

English

Date

2024

Rights

This work is licensed under a
CC BY 4.0 - Creative Commons Attribution 4.0 International License.

CC BY 4.0 International

http://creativecommons.org/licenses/by/4.0/

Classification

Brain Transfer Constants; Graphical Evaluation; Input Function; F-18-Fdg Pet; Liver; Kinetics; Mice

Member of the Collection(s) (1)