Title (en)
Characterization of a Syngeneic Orthotopic Model of Cholangiocarcinoma by [18F]FDG-PET/MRI
Language
English
Description (en)
Cholangiocarcinoma (CCA) is a type of primary liver cancer originating from the biliary tract epithelium, characterized by limited treatment options for advanced cases and low survival rates. This study aimed to establish an orthotopic mouse model for CCA and monitor tumor growth using PET/MR imaging. Murine CCA cells were implanted into the liver lobe of male C57BL/6J mice. The imaging groups included contrast-enhanced (CE) MR, CE-MR with static [18F]FDG-PET, and dynamic [18F]FDG-PET. Tumor volume and FDG uptake were measured weekly over four weeks. Early tumor formation was visible in CE-MR images, with a gradual increase in volume over time. Dynamic FDG-PET revealed an increase in the metabolic glucose rate (MRGlu) over time. Blood analysis showed pathological changes in liver-related parameters. Lung metastases were observed in nearly all animals after four weeks. The study concludes that PET-MR imaging effectively monitors tumor progression in the CCA mouse model, providing insights into CCA development and potential treatment strategies.
Keywords (en)
Brain Transfer Constants; Graphical Evaluation; Input Function; F-18-Fdg Pet; Liver; Kinetics; Mice
DOI
10.3390/cancers16142591
Author of the digital object
Lena Zachhuber (University of Vienna / Medical University of Vienna)
Claudia Kuntner (Medical University of Vienna)
Walter Berger (Medical University of Vienna)
Thomas Wanek (Medical University of Vienna)
Thomas H. Helbich (Medical University of Vienna)
Marcus Hacker (Medical University of Vienna)
Johann Stanek (Medical University of Vienna)
Petra Vician (Medical University of Vienna)
Stefan Scheiner (Medical University of Vienna)
Mathilde Löbsch (Medical University of Vienna)
Thomas Filip (University of Veterinary Medicine Vienna)
Behrang Mozayani (Medical University of Vienna)
Format
application/pdf
Size
4.6 MB
Licence Selected
CC BY 4.0 International
Type of publication
Article
Name of Publication (en)
Cancers
Pages or Volume
18
Volume
16
Number
45
Publisher
MDPI
Publication Date
2024
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DOI
https://phaidra.vetmeduni.ac.at/o:3493
https://doi.org/10.3390/cancers16142591 - DetailsObject typePDFDocumentFormatapplication/pdfCreated06.09.2024 09:41:15
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