Title
Characterization of a Syngeneic Orthotopic Model of Cholangiocarcinoma by [18F]FDG-PET/MRI
Language
English
Description (en)
Cholangiocarcinoma (CCA) is a type of primary liver cancer originating from the biliary tract epithelium, characterized by limited treatment options for advanced cases and low survival rates. This study aimed to establish an orthotopic mouse model for CCA and monitor tumor growth using PET/MR imaging. Murine CCA cells were implanted into the liver lobe of male C57BL/6J mice. The imaging groups included contrast-enhanced (CE) MR, CE-MR with static [18F]FDG-PET, and dynamic [18F]FDG-PET. Tumor volume and FDG uptake were measured weekly over four weeks. Early tumor formation was visible in CE-MR images, with a gradual increase in volume over time. Dynamic FDG-PET revealed an increase in the metabolic glucose rate (MRGlu) over time. Blood analysis showed pathological changes in liver-related parameters. Lung metastases were observed in nearly all animals after four weeks. The study concludes that PET-MR imaging effectively monitors tumor progression in the CCA mouse model, providing insights into CCA development and potential treatment strategies.
Keywords (en)
Brain Transfer Constants; Graphical Evaluation; Input Function; F-18-Fdg Pet; Liver; Kinetics; Mice
DOI
10.3390/cancers16142591
Author of the digital object
Lena  Zachhuber  (University of Vienna / Medical University of Vienna)
Claudia  Kuntner  (Medical University of Vienna)
Walter  Berger  (Medical University of Vienna)
Thomas  Wanek  (Medical University of Vienna)
Thomas H.  Helbich  (Medical University of Vienna)
Marcus  Hacker  (Medical University of Vienna)
Johann  Stanek  (Medical University of Vienna)
Petra  Vician  (Medical University of Vienna)
Stefan  Scheiner  (Medical University of Vienna)
Mathilde  Löbsch  (Medical University of Vienna)
Thomas  Filip  (University of Veterinary Medicine Vienna)
Behrang  Mozayani  (Medical University of Vienna)
Format
application/pdf
Size
4.6 MB
Licence Selected
CC BY 4.0 International
Type of publication
Article
Name of Publication (en)
Cancers
Pages or Volume
18
Volume
16
Number
45
Publisher
MDPI
Publication Date
2024
Content
Details
Object type
PDFDocument
Format
application/pdf
Created
06.09.2024 09:41:15
This object is in collection
Metadata
Veterinärmedizinische Universität Wien (Vetmeduni) | Veterinärplatz 1 | 1210 Wien - Österreich | T +43 1 25077-0 | Web: vetmeduni.ac.at