Title
Immunotherapy of Equine Sarcoids-From Early Approaches to Innovative Vaccines
Language
English
Description (en)
Horses and other equid species are frequently affected by bovine papillomavirus type 1 and/or 2 (BPV1, BPV2)-induced skin tumors termed sarcoids. Although sarcoids do not metastasize, they constitute a serious health problem due to their BPV1/2-mediated resistance to treatment and propensity to recrudesce in a more severe, multiple form following accidental or iatrogenic trauma. This review provides an overview on BPV1/2 infection and associated immune escape in the equid host and presents early and recent immunotherapeutic approaches in sarcoid management.
Keywords (en)
Bovine Papillomavirus Type-1; Virus-Like Particles; Regulatory T-Cell; Leukocyte Antigens; Tumor-Cells; Human Interleukin-2; Immune-Response; Gene-Expression; Dna; Protein
DOI
10.3390/vaccines11040769
Author of the digital object
Christoph Jindra (University of Veterinary Medicine Vienna / Karl Landsteiner University of Health Sciences)
Sabine Brandt (University of Veterinary Medicine Vienna)
Edmund K. Hainisch (University of Veterinary Medicine Vienna)
Format
application/pdf
Size
402.1 kB
Licence Selected
CC BY 4.0 International
Type of publication
Article
Name of Publication (en)
Vaccines
Pages or Volume
13
Volume
11
Number
4
Publisher
MDPI
Publication Date
2023
Citable links
Persistent identifier
https://phaidra.vetmeduni.ac.at/o:1630
https://doi.org/10.3390/vaccines11040769
Content
Details
Object type
PDFDocument
Format
application/pdf
Created
31.05.2023 09:17:12
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