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Title (en)
Papillomavirus-like Particles in Equine Medicine
Language
English
Description (en)
Papillomaviruses (PVs) are a family of small DNA tumor viruses that can induce benign lesions or cancer in vertebrates. The observation that animal PV capsid-proteins spontaneously self-assemble to empty, highly immunogenic virus-like particles (VLPs) has led to the establishment of vaccines that efficiently protect humans from specific PV infections and associated diseases. We provide an overview of PV-induced tumors in horses and other equids, discuss possible routes of PV transmission in equid species, and present recent developments aiming at introducing the PV VLP-based vaccine technology into equine medicine.
Keywords (en)
Humans; Animals; Horses; Papillomaviridaegenetics; Capsid; Capsid Proteinsgenetics
DOI
10.3390/v15020345
Author of the digital object
Edmund K Hainisch  (University of Veterinary Medicine, Vienna)
Sabine Brandt  (University of Veterinary Medicine, Vienna)
Reinhard Kirnbauer  (Medical University of Vienna)
Christoph Jindra  (University of Veterinary Medicine, Vienna / Karl Landsteiner University of Health Sciences)
Format
application/pdf
Size
9.5 MB
Licence Selected
CC BY 4.0 International
Type of publication
Article
Name of Publication (en)
Viruses
Pages or Volume
12
Volume
15
Number
2
Publisher
MDPI
Publication Date
2023