Glycans of parasitic nematodes - from glycomes to novel diagnostic tools and vaccines

Shi Yan

doi:10.1016/j.carres.2025.109407

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Title (eng)

Glycans of parasitic nematodes - from glycomes to novel diagnostic tools and vaccines

Author

Shi Yan

University of Veterinary Medicine Vienna

Abstract (eng)

Nematodes, commonly known as roundworms, are among the most prevalent and diverse multicellular organisms on Earth, belonging to the large phylum Nematoda. In addition to free-living species, many nematodes are parasitic, infecting plants, animals, and humans. Nematodes possess a wide array of genes responsible for carbohydrate metabolism and glycosylation. The glycosylation processes in parasitic nematodes often result in unique glycan modifications that are not present in their hosts. These distinct glycans can be highly immunogenic to mammalian hosts and play significant immunoregulatory roles during infection. This mini-review article summarises the glycosylation capabilities and characteristics of parasitic nematodes based on glycomic data. It also highlights recent research advances that explore the biological significance of nematode glycans and their potential for diagnostic and vaccine applications.

Keywords (eng)

Polysaccharides ChemistryPolysaccharides ImmunologyAnimalsNematoda ImmunologyNematoda ChemistryVaccines ImmunologyVaccines ChemistryHumansGlycosylationGlycomics

Type (eng)

journal article

Language

[eng]

Persistent identifier

https://phaidra.vetmeduni.ac.at/o:3966

DOI

10.1016/j.carres.2025.109407

Is in series

Title (eng)

Carbohydrate Research

Volume