Title
Screening for oncogenic AF1q expression predicts disease recurrence in gastric cancer patients
Language
English
Description (en)
AF1q associates with tumor progression and metastases upon WNT signaling. The downstream WNT target CD44 has demonstrated prognostic significance in gastric cancer (GC). This study evaluates the impact of AF1q on tumor stage and survival in GC patients. Immunohistochemical marker expression was analyzed and data were processed to correlation and survival analysis. Out of 182 GC samples, 178 (97.8%) showed moderate to high AF1q expression (p < 0.001), these samples correlated with positive lymph node stage (p = 0.036). In a subgroup analysis of patients with nodal-positive GC (n = 129, 70.9%), enhanced tumoral AF1q expression resulted in impaired recurrence-free survival (RFS, p = 0.030). Enhanced tumoral CD44 expression resulted in impaired disease-specific survival (DSS) in the subgroup of patients with nodal-positive GC (p = 0.031) as well as in the overall GC group (p = 0.005). AF1q demonstrated as an independent prognostic marker for RFS (p = 0.035) and CD44 for DSS (p = 0.036). AF1q has shown potential for prognostication of RFS in GC patients and is predominantly expressed in nodal-positive GC. Testing AF1q provides a possibility of identifying patients with locoregional (and advanced) disease, particularly at risk for disease recurrence. Implementing AF1q into the diagnostic process may facilitate screening, prognosis estimation as well as consideration of preoperative multimodal treatment in patients qualifying for elective upfront surgery.
Keywords (en)
AF1q; CD44; Lymph node stage; Recurrence; Survival; Gastric cancer
DOI
10.1038/s41598-024-67058-x
Author of the digital object
Elisabeth S.  Gruber  (Medical University of Vienna)
Lukas  Kenner  (University of Veterinary Medicine Vienna / Medical University of Vienna / Center For Biomarker Research In Medicine)
William  Tse  (Case Western Reserve University)
Gerd  Jomrich  (Medical University of Vienna)
Peter  Birner  (Medical University of Vienna)
Georg  Oberhuber  (Medical University of Vienna / PIZ - patho im zentrum GmbH)
Sebastian F.  Schoppmann  (Medical University of Vienna)
Michaela  Schlederer  (Medical University of Vienna)
Format
application/pdf
Size
1.5 MB
Licence Selected
CC BY 4.0 International
Type of publication
Article
Name of Publication (en)
Scientific Reports
Pages or Volume
8
Volume
14
Number
1
Publisher
Nature
Publication Date
2024
Content
Details
Object type
PDFDocument
Format
application/pdf
Created
09.09.2024 07:00:21
This object is in collection
Metadata
University of Veterinary Medicine Vienna (Vetmeduni Vienna) | Veterinärplatz 1 | A-1210 Vienna | Austria | T +43 1 25077-0