Title (eng)

Functional mapping of the somatosensory cortex using noninvasive fMRI and touch in awake dogs

Author

C-N Alexandrina Guran   University of Vienna

Claus Lamm   University of Vienna

Ludwig Huber   University of Veterinary Medicine Vienna

Sabrina Karl   University of Veterinary Medicine Vienna

Lucrezia Lonardo   University of Veterinary Medicine Vienna

Magdalena Boch   University of Vienna

Ronald Sladky   University of Vienna

Publishing

Springer

Description (eng)

Dogs are increasingly used as a model for neuroscience due to their ability to undergo functional MRI fully awake and unrestrained, after extensive behavioral training. Still, we know rather little about dogs' basic functional neuroanatomy, including how basic perceptual and motor functions are localized in their brains. This is a major shortcoming in interpreting activations obtained in dog fMRI. The aim of this preregistered study was to localize areas associated with somatosensory processing. To this end, we touched N?=?22 dogs undergoing fMRI scanning on their left and right flanks using a wooden rod. We identified activation in anatomically defined primary and secondary somatosensory areas (SI and SII), lateralized to the contralateral hemisphere depending on the side of touch, and importantly also activation beyond SI and SII, in the cingulate cortex, right cerebellum and vermis, and the sylvian gyri. These activations may partly relate to motor control (cerebellum, cingulate), but also potentially to higher-order cognitive processing of somatosensory stimuli (rostral sylvian gyri), and the affective aspects of the stimulation (cingulate). We also found evidence for individual side biases in a vast majority of dogs in our sample, pointing at functional lateralization of somatosensory processing. These findings not only provide further evidence that fMRI is suited to localize neuro-cognitive processing in dogs, but also expand our understanding of in vivo touch processing in mammals, beyond classically defined primary and secondary somatosensory cortices.

Object languages

English

Date

2024

Rights

Creative Commons License
This work is licensed under a
CC BY 4.0 - Creative Commons Attribution 4.0 International License.

CC BY 4.0 International

http://creativecommons.org/licenses/by/4.0/

Classification

Keywords: Animals; Dogs; Magnetic Resonance Imagingmethods; Somatosensory Cortexphysiologydiagnostic imaging; Brain Mappingmethods; Male; Female; Wakefulnessphysiology; Functional Lateralityphysiology; Touchphysiology; Touch Perceptionphysiology; Physical Stimulation

Member of the Collection(s) (1)

o:605 Publications / University of Veterinary Medicine Vienna