Titel (eng)

Molecular evolution of the pathogen recognition peptidoglycan proteins regulates the immune response against infectious diseases in Drosophila melanogaster

Autor*in

Muhammad Ehsan Khalid   Rural Health Center Shah Sadar Deen

Gokhlesh Kumar   University of Veterinary Medicine Vienna

Mohammed H.A. Almarzoug   King Saud University

Daoud Ali   King Saud University

Fahad Saleem   Punjab Medical College Faisalabad

Maryam Raana   King Edward Medical University

Syed Aun Muhammad   University of Veterinary and Animal Sciences

Abdur Rahman   University of Veterinary and Animal Sciences

Muhammad Essa   King Edward Medical University

Afifa Zafar   Islam Medical College

Zubia Zafar   Women Medical Officer Basic Health Unit

Hafiz Ishfaq Ahmad   The Islamia University of Bahawalpur

Akhtar Rasool Asif   University of Veterinary and Animal Sciences / Huazhong Agricultural University

Verlag

Elsevier

Beschreibung (eng)

The study aimed to understand the molecular evolution of the pathogen recognition peptidoglycan (PGN) proteins and their role in regulating the immune response against infectious diseases in Drosophila melanogaster. D. melanogasterWe obtained the PGRP proteins from 11 different species of Drosophila and analyzed the different evolutionary trends that might be associated with them. We were able to identify the evidence of strong positive selection taking place for these proteins. We investigated the diversity and function of the PGN proteins in D. melanogaster and related species through a combination of bioinformatics approaches. They found that the PGN proteins have undergone rapid and diverse evolution, with some undergoing positive selection and others experiencing gene duplication and loss. The study also revealed that different PGN proteins play distinct roles in regulating the immune response to bacterial infections, with some responding specifically to certain types of bacteria. The research provides valuable insights into the evolution and function of the PGN proteins in the immune response of D. melanogaster. It highlights their potential relevance to pathogen recognition and immune defence in other organisms.

Sprache des Objekts

Englisch

Datum

2023

Rechte

Dieses Werk bzw. dieser Inhalt steht unter einer
CC BY-NC-ND 4.0 - Creative Commons Namensnennung - Nicht-kommerziell - Keine Bearbeitungen 4.0 International Lizenz.

CC BY-NC-ND 4.0 International

http://creativecommons.org/licenses/by-nc-nd/4.0/

Klassifikation

Adaptive immunity; Darwinian selection; Drosophila; Molecular evolution; PGRP

Mitglied in der/den Collection(s) (1)