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Title (en)
A Narrative Review: The Effect and Importance of Carotenoids on Aging and Aging-Related Diseases
Language
English
Description (en)
Aging is generally defined as a time-dependent functional decline that affects most living organisms. The positive increase in life expectancy has brought along aging-related diseases. Oxidative stress caused by the imbalance between pro-oxidants and antioxidants can be given as one of the causes of aging. At the same time, the increase in oxidative stress and reactive oxygen species (ROS) is main reason for the increase in aging-related diseases such as cardiovascular, neurodegenerative, liver, skin, and eye diseases and diabetes. Carotenoids, a natural compound, can be used to change the course of aging and aging-related diseases, thanks to their highly effective oxygen-quenching and ROS-scavenging properties. Therefore, in this narrative review, conducted using the PubMed, ScienceDirect, and Google Scholar databases and complying with the Scale for the Assessment of Narrative Review Articles (SANRA) guidelines, the effects of carotenoids on aging and aging-related diseases were analyzed. Carotenoids are fat-soluble, highly unsaturated pigments that occur naturally in plants, fungi, algae, and photosynthetic bacteria. A large number of works have been conducted on carotenoids in relation to aging and aging-related diseases. Animal and human studies have found that carotenoids can significantly reduce obesity and fatty liver, lower blood sugar, and improve liver fibrosis in cirrhosis, as well as reduce the risk of cardiovascular disease and erythema formation, while also lowering glycated hemoglobin and fasting plasma glucose levels. Carotenoid supplementation may be effective in preventing and delaying aging and aging-related diseases, preventing and treating eye fatigue and dry eye disease, and improving macular function. These pigments can be used to stop, delay, or treat aging-related diseases due to their powerful antioxidant, restorative, anti-proliferative, anti-inflammatory, and anti-aging properties. As an increasingly aging population emerges globally, this review could provide an important prospective contribution to public health.
Keywords (en)
Oxidative Stress; Metabolic Syndrome; Diabetes-Mellitus; Lower Prevalence; Binding Protein; Beta-Carotene; Astaxanthin; Lutein; Lycopene; Risk
DOI
10.3390/ijms242015199
Author of the digital object
Elif Rabia Bakac  (Bezmialem Vakif University)
Agnes Dadak  (University of Veterinary Medicine Vienna)
Ece Percin  (Bezmialem Vakif University)
Ayse Gunes-Bayir  (Bezmialem Vakif University)
Format
application/pdf
Size
516.6 kB
Licence Selected
CC BY 4.0 International
Type of publication
Article
Name of Publication (en)
International Journal of Molecular Sciences
Pages or Volume
16
Volume
24
Number
20
Publisher
MDPI
Publication Date
2023