You are here:
  1. PHAIDRA
  2. Detail o:2422
Open in new window
Title (en)
Histone Variants and Their Chaperones in Hematological Malignancies
Language
English
Description (en)
Epigenetic regulation occurs on the level of compacting DNA into chromatin. The functional unit of chromatin is the nucleosome, which consists of DNA wrapped around a core of histone proteins. While canonical histone proteins are incorporated into chromatin through a replication-coupled process, structural variants of histones, commonly named histone variants, are deposited into chromatin in a replication-independent manner. Specific chaperones and chromatin remodelers mediate the locus-specific deposition of histone variants. Although histone variants comprise one of the least understood layers of epigenetic regulation, it has been proposed that they play an essential role in directly regulating gene expression in health and disease. Here, we review the emerging evidence suggesting that histone variants have a role at different stages of hematopoiesis, with a particular focus on the histone variants H2A, H3, and H1. Moreover, we discuss the current knowledge on how the dysregulation of histone variants can contribute to hematopoietic malignancies.
Keywords (en)
Acute Myeloid-Leukemia; Myelodysplastic Syndromes; Chromatin Accessibility; Frequent Mutation; Gene-Expression; H1 Variants; H2a.Z; Cancer; Hira; H3.3
DOI
10.1097/HS9.0000000000000927
Author of the digital object
Ecem Kirkiz  (University of Veterinary Medicine Vienna)
Marcus Buschbeck  (Campus Can Ruti / University of Barcelona)
Florian Grebien  (University of Veterinary Medicine Vienna / St. Anna Children's Cancer Research Institute)
Oliver Meers  (Campus Can Ruti / University of Barcelona)
Format
application/pdf
Size
541.0 kB
Licence Selected
CC BY 4.0 International
Type of publication
Article
Name of Publication (en)
HemaSphere
Pages or Volume
10
Volume
7
Number
8
Publisher
Lipponcott Williams & Wilkins
Publication Date
2023