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Title (en)
Cyclin-dependent kinase inhibitors in malignant hematopoiesis
Language
English
Description (en)
The cell-cycle is a tightly orchestrated process where sequential steps guarantee cellular growth linked to a correct DNA replication. The entire cell division is controlled by cyclin-dependent kinases (CDKs). CDK activation is balanced by the activating cyclins and CDK inhibitors whose correct expression, accumulation and degradation schedule the time-flow through the cell cycle phases. Dysregulation of the cell cycle regulatory proteins causes the loss of a controlled cell division and is inevitably linked to neoplastic transformation. Due to their function as cell-cycle brakes, CDK inhibitors are considered as tumor suppressors. The CDK inhibitors p16INK4a and p15INK4b are among the most frequently altered genes in cancer, including hematopoietic malignancies. Aberrant cell cycle regulation in hematopoietic stem cells (HSCs) bears severe consequences on hematopoiesis and provokes hematological disorders with a broad array of symptoms. In this review, we focus on the importance and prevalence of deregulated CDK inhibitors in hematological malignancies.
Keywords (en)
Acute Lymphoblastic-Leukemia; Tumor-Suppressor Gene; Aberrant Dna Methylation; Squamous-Cell Carcinoma; Polycomb-Group Genes; Stem-Cell; Cdk Inhibitor; Prognostic-Significance; Mice Lacking; T-Cell
DOI
10.3389/fonc.2022.916682
Author of the digital object
Alessia Schirripa  (University of Veterinary Medicine Vienna)
Veronika Sexl  (University of Veterinary Medicine Vienna)
Karoline Kollmann  (University of Veterinary Medicine Vienna)
Format
application/pdf
Size
379.6 kB
Licence Selected
CC BY 4.0 International
Type of publication
Article
Name of Publication (en)
Frontiers in Oncology
Pages or Volume
18
Volume
12
Publisher
Frontiers Media Sa
Publication Date
2022